HitPredict

Interactor 1: MYPT2 (O60237)
Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2)
Gene: PPP1R12B

Interactor 2: PP1B (P62140)
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)
Gene: PPP1CB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.739

Property	Details
Experiments	26496610, 27880917, 28330616, 26871637, 9570949, 33961781
Identification Methods	affinity chromatography technology, proximity labelling technology, two hybrid, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 982 Hs			1 327
+	Hs
		225132 MYPT2_HUMAN (1-982): 7.66e-163: 505: 100.00		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Hs
		225129 MYPT2_HUMAN (1-982): 7.66e-163: 505: 100.00		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Mm
		906293 MYPT2_MOUSE (1-982): 6.91e-153: 479: 89.72		PP1A_MOUSE (1-326): 0: 576: 88.49
+	Hs
		906572 PP16B_HUMAN (10-383): 1.65e-86: 291: 31.70		PP1B_HUMAN (1-327): 0: 597: 100.00
+	Hs
		906561 PP16A_HUMAN (1-310): 4.98e-81: 274: 37.46		PP1B_HUMAN (1-327): 0: 597: 100.00
+	Dm
		115663 M9PFV2_DROME (10-466): 1e-89: 301: 28.60		PP1B_DROME (1-322): 0: 568: 90.37
+	Dm
		819281 Q8SY34_DROME (10-466): 1.01e-87: 299: 28.60		PP1B_DROME (1-322): 0: 568: 90.37
+	Hs
		906099 PP16B_HUMAN (10-383): 1.65e-86: 291: 31.70		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Hs
		737999 PP16B_HUMAN (10-383): 1.65e-86: 291: 31.70		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Ce
		1099876 Q95ZS1_CAEEL (62-464): 7.08e-87: 289: 28.26		GLC7A_CAEEL (3-317): 0: 569: 92.38
+	Ce
		953872 P90902_CAEEL (62-464): 1.06e-86: 288: 28.57		GLC7A_CAEEL (3-317): 0: 569: 92.38
+	Hs
		906079 PP16A_HUMAN (1-310): 4.98e-81: 274: 37.46		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Dm
		1249016 Q8SY34_DROME (10-466): 1.01e-87: 299: 28.60		Q8T0U6_DROME (18-322): 0: 550: 91.48
+	Dm
		115662 M9PFV2_DROME (10-466): 1e-89: 301: 28.60		PP12_DROME (6-303): 0: 546: 88.59
+	Hs
		737978 PP16A_HUMAN (1-310): 4.98e-81: 274: 37.46		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Hs
		906005 MIB1_HUMAN (2-397): 4.04e-73: 263: 18.75		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Dm
		819272 Q86R99_DROME (197-982): 2.74e-67: 243: 20.39		PP1B_DROME (1-322): 0: 568: 90.37
+	Hs
		905838 ANK2_HUMAN (38-320): 2.2e-60: 228: 21.58		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Mm
		906252 PP12C_MOUSE (224-982): 5.15e-55: 207: 18.07		PP1A_MOUSE (1-326): 0: 576: 88.49
+	Hs
		738024 PP12C_HUMAN (224-982): 6.74e-53: 200: 17.93		PP1G_HUMAN (1-327): 0: 569: 86.89