HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: CSN2 (P61201)
COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15)
Gene: COPS2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 443
+	Hs
		121640 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSD11_HUMAN (35-442): 5.44e-89: 278: 22.43
+	Hs
		227483 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSMD6_HUMAN (55-440): 4.29e-87: 272: 13.01
+	Hs
		121897 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSD12_HUMAN (39-440): 8.69e-83: 263: 12.80
+	Hs
		227323 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02
+	Hs
		228529 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CSN4_HUMAN (54-440): 8.14e-74: 238: 16.25
+	Hs
		475555 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CSN2_HUMAN (1-443): 3.15e-127: 377: 100.00
+	Sc
		477496 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		RPN6_YEAST (67-443): 8.69e-76: 245: 21.43
+	Hs
		121666 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSD11_HUMAN (35-442): 5.44e-89: 278: 22.43
+	Hs
		475779 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSMD6_HUMAN (55-440): 4.29e-87: 272: 13.01
+	Hs
		121918 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSD12_HUMAN (39-440): 8.69e-83: 263: 12.80
+	At
		1092149 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSD11_ARATH (42-443): 2.17e-80: 256: 22.98
+	At
		1092027 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PS12A_ARATH (43-440): 7.05e-75: 242: 10.14
+	Hs
		476293 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CSN4_HUMAN (54-440): 8.14e-74: 238: 16.25
+	At
		1091832 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PS12B_ARATH (43-440): 1.95e-73: 238: 10.60
+	At
		1091885 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSMD6_ARATH (79-440): 2.11e-72: 234: 15.32
+	At
		799469 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CSN1_ARATH (231-442): 2.95e-44: 162: 21.15