HitPredict

Interactor 1: NCK2 (O55033)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: SRBS1 (Q62417)
Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)
Gene: Sorbs1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	11557983
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SH2~SH3_1, SH2~SH3_2, SH3_1~SH3_1, SH3_1~SH3_2, SH3_2~SH3_9, SH3_9~SH3_9
Common GO terms	GO:0005829 - cytosol GO:0045202 - synapse
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 380 Mm			1 1290
+	Hs
		221992 NCK2_HUMAN (1-380): 6.22e-94: 287: 96.05		SRBS2_HUMAN (133-1288): 3.79e-127: 422: 25.52
+	Hs
		222190 NCK2_HUMAN (1-380): 6.22e-94: 287: 96.05		SRBS1_HUMAN (1-1290): 1.37e-55: 214: 20.61
+	Hs
		250203 NCK1_HUMAN (1-379): 1.44e-89: 276: 66.40		VINEX_HUMAN (812-1288): 3.77e-43: 170: 30.44
+	Hs
		221982 NCK2_HUMAN (1-380): 6.22e-94: 287: 96.05		NCK2_HUMAN (973-1208): 5.92e-20: 95.7: 20.97
+	Hs
		3271 A0A0S2Z4D7_HUMAN (1-138): 3.27e-60: 193: 67.39		VINEX_HUMAN (812-1288): 3.77e-43: 170: 30.44
+	Hs
		593961 NCK1_HUMAN (1-379): 1.44e-89: 276: 66.40		GRB2_HUMAN (1233-1286): 2.91e-15: 78.4: 32.73
+	Hs
		222014 NCK2_HUMAN (1-380): 6.22e-94: 287: 96.05		NCK1_HUMAN (1129-1285): 3.57e-09: 62.4: 31.48
+	Hs
		593897 NCK1_HUMAN (1-379): 1.44e-89: 276: 66.40		NCK1_HUMAN (1129-1285): 3.57e-09: 62.4: 31.48
+	Ce
		758547 Q95PW9_CAEEL (1-379): 1.16e-73: 236: 38.38		YKA7_CAEEL (957-1286): 3.19e-21: 101: 18.73
+	Hs
		1453434 ITSN2_HUMAN (5-306): 2.8e-33: 133: 18.51		ITSN2_HUMAN (474-1288): 5.37e-34: 145: 11.06
+	Hs
		584478 P85A_HUMAN (26-379): 1.65e-27: 116: 12.33		VAV_HUMAN (542-1289): 2.5e-34: 144: 10.27
+	Hs
		1384281 ITSN2_HUMAN (5-306): 2.8e-33: 133: 18.51		SH3K1_HUMAN (1022-1109): 7.87e-12: 71.8: 27.10
+	Hs
		618986 P85A_HUMAN (26-379): 1.65e-27: 116: 12.33		PLCG1_HUMAN (1137-1288): 3.88e-15: 83.2: 19.08
+	Hs
		1154182 ITSN2_HUMAN (5-306): 2.8e-33: 133: 18.51		ITSN1_HUMAN (773-1288): 1.63e-09: 64.7: 9.76
+	Mm
		686966 P85A_MOUSE (26-379): 4.76e-28: 117: 12.33		GRB2_MOUSE (1233-1286): 2.91e-15: 78.4: 32.73
+	Hs
		699686 P85A_HUMAN (26-379): 1.65e-27: 116: 12.33		GRB2_HUMAN (1233-1286): 2.91e-15: 78.4: 32.73
+	Hs
		699824 P85A_HUMAN (26-379): 1.65e-27: 116: 12.33		SH3K1_HUMAN (1022-1109): 7.87e-12: 71.8: 27.10
+	Hs
		699767 P85A_HUMAN (26-379): 1.65e-27: 116: 12.33		ITSN1_HUMAN (773-1288): 1.63e-09: 64.7: 9.76
+	Hs
		593920 P85A_HUMAN (26-379): 1.65e-27: 116: 12.33		NCK1_HUMAN (1129-1285): 3.57e-09: 62.4: 31.48