HitPredict

Interactor 1: KLK8 (O60259)
Kallikrein-8 (hK8) (EC 3.4.21.118) (Neuropsin) (NP) (Ovasin) (Serine protease 19) (Serine protease TADG-14) (Tumor-associated differentially expressed gene 14 protein)
Gene: KLK8

Interactor 2: VWDE (Q8N2E2)
von Willebrand factor D and EGF domain-containing protein
Gene: VWDE

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 260 Hs			1 1590
+	Hs
		455655 KLK3_HUMAN (13-259): 1.21e-102: 300: 39.84		VWDE_HUMAN (1-1590): 0: 2157: 100.00
+	Hs
		1324224 KLK15_HUMAN (23-259): 8.53e-101: 295: 45.57		VWDE_HUMAN (1-1590): 0: 2157: 100.00
+	Hs
		634784 GRAH_HUMAN (28-256): 4.13e-43: 148: 37.29		VWDE_HUMAN (1-1590): 0: 2157: 100.00
+	Hs
		663560 CMA1_HUMAN (26-256): 1.09e-39: 139: 36.67		VWDE_HUMAN (1-1590): 0: 2157: 100.00
+	Hs
		628475 KLK2_HUMAN (12-259): 1.94e-107: 312: 41.63		JAG2_HUMAN (1286-1588): 1.31e-20: 101: 19.31
+	Hs
		1432129 KLK15_HUMAN (23-259): 8.53e-101: 295: 45.57		JAG2_HUMAN (1286-1588): 1.31e-20: 101: 19.31
+	Hs
		1448854 TMPS4_HUMAN (6-259): 8.21e-95: 287: 31.46		JAG2_HUMAN (1286-1588): 1.31e-20: 101: 19.31
+	Hs
		1047787 KLK5_HUMAN (24-259): 4.61e-98: 290: 47.48		NOTC2_HUMAN (886-1221): 3.38e-12: 74.1: 12.64
+	Hs
		437665 HEPS_HUMAN (15-257): 3.9e-95: 287: 31.32		NOTC2_HUMAN (886-1221): 3.38e-12: 74.1: 12.64
+	Mm
		204901 CFAD_MOUSE (15-255): 5.99e-45: 153: 38.65		NOTC2_MOUSE (888-1304): 3.6e-22: 106: 10.21
+	Hs
		518735 GRAB_HUMAN (27-256): 1.37e-39: 139: 37.08		NOTC1_HUMAN (889-1333): 4.51e-26: 119: 11.67
+	Hs
		663579 CMA1_HUMAN (26-256): 1.09e-39: 139: 36.67		JAG2_HUMAN (1286-1588): 1.31e-20: 101: 19.31
+	Mm
		405588 GRAB_MOUSE (26-258): 1.94e-43: 149: 35.42		NOTC1_MOUSE (1454-1590): 9.98e-16: 85.6: 27.16
+	Mm
		398550 CFAD_MOUSE (15-255): 5.99e-45: 153: 38.65		SNED1_MOUSE (885-1034): 5.68e-12: 73.3: 15.29
+	Mm
		398456 CFAD_MOUSE (15-255): 5.99e-45: 153: 38.65		LAMA5_MOUSE (1448-1587): 1.49e-10: 68.7: 16.33
+	Hs
		183219 GRAB_HUMAN (27-256): 1.37e-39: 139: 37.08		LAMA5_HUMAN (923-1183): 5.98e-10: 66.7: 8.90