HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PSB2 (P49721)
Proteasome subunit beta type-2 (Macropain subunit C7-I) (Multicatalytic endopeptidase complex subunit C7-I) (Proteasome component C7-I) (Proteasome subunit beta-4) (beta-4)
Gene: PSMB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35256949, 23503661
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 201
+	Hs
		240822 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSB5_HUMAN (2-197): 1.97e-66: 206: 17.86
+	Hs
		240796 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSA4_HUMAN (3-198): 5.78e-65: 202: 17.73
+	Hs
		242681 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSB7_HUMAN (3-199): 1.33e-64: 202: 19.80
+	Hs
		240794 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSA2_HUMAN (4-197): 1.05e-64: 201: 17.86
+	Hs
		240732 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSB1_HUMAN (3-198): 2.08e-57: 182: 23.42
+	Hs
		240959 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSB10_HUMAN (3-199): 1.91e-45: 153: 21.83
+	Hs
		240821 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSB6_HUMAN (3-188): 2.97e-44: 148: 17.74
+	Hs
		633741 CUL9_HUMAN (30-463): 4.64e-78: 267: 18.81		PSB1_HUMAN (3-198): 2.08e-57: 182: 23.42
+	Zm
		28812 A0A1D6JU68_MAIZE (231-460): 5.9e-56: 197: 27.24		C0PFF5_MAIZE (1-190): 5.76e-81: 241: 44.21
+	Sc
		509399 UBI4P_YEAST (1-229): 3.44e-60: 203: 18.72		PSB4_YEAST (1-193): 1.26e-78: 235: 44.85
+	Hs
		507088 UBB_HUMAN (1-234): 4.43e-61: 200: 17.92		PSA4_HUMAN (3-198): 5.78e-65: 202: 17.73
+	Hs
		507087 UBB_HUMAN (1-234): 4.43e-61: 200: 17.92		PSA2_HUMAN (4-197): 1.05e-64: 201: 17.86
+	At
		200658 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSB2A_ARATH (1-190): 4.78e-78: 233: 45.79
+	At
		201197 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSB2B_ARATH (1-190): 7.6e-77: 230: 45.26
+	Zm
		35458 Q42415_MAIZE (1-153): 6.6e-50: 179: 20.13		A0A1D6LKR2_MAIZE (3-190): 9.33e-47: 155: 17.71
+	At
		200665 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSB5A_ARATH (2-198): 1.27e-67: 209: 21.83
+	At
		200646 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSA2A_ARATH (2-197): 1.84e-66: 205: 18.09
+	At
		200652 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSB7A_ARATH (3-198): 1.34e-63: 199: 18.88
+	At
		201186 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSA7B_ARATH (4-196): 8.91e-64: 199: 16.16
+	Zm
		35457 Q41754_MAIZE (1-76): 1.2e-29: 121: 31.58		A0A1D6LKR2_MAIZE (3-190): 9.33e-47: 155: 17.71