HitPredict

Interactor 1: BRD4 (O60885)
Bromodomain-containing protein 4 (Protein HUNK1)
Gene: BRD4

Interactor 2: MEP50 (Q9BQA1)
Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50)
Gene: WDR77

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31239290
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1362 Hs			1 342
+	Hs
		244908 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		WDR33_HUMAN (58-331): 3.52e-67: 230: 17.86
+	Hs
		244027 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		COPB2_HUMAN (54-331): 3.17e-47: 172: 18.38
+	Hs
		243688 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		TBL1X_HUMAN (162-342): 3.97e-28: 116: 15.46
+	Hs
		244901 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		TBL1R_HUMAN (206-337): 3.38e-19: 90.1: 13.01
+	Hs
		244210 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79
+	Hs
		196921 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		PRP4_HUMAN (253-341): 3.86e-10: 62.8: 13.40
+	Hs
		631541 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		FBXW7_HUMAN (3-236): 5.23e-43: 159: 14.29
+	Hs
		631433 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		TAF5_HUMAN (178-328): 1.2e-21: 98: 18.42
+	Sc
		744679 GCN5_YEAST (140-462): 1.42e-41: 161: 16.37		TAF5_YEAST (15-267): 2.96e-38: 146: 14.77
+	Hs
		1066968 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		TAF5_HUMAN (178-328): 1.2e-21: 98: 18.42
+	Sp
		252179 YK82_SCHPO (49-215): 1.43e-35: 147: 26.35		NLE1_SCHPO (204-340): 4.1e-33: 129: 16.55
+	Hs
		196957 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		PRP4_HUMAN (253-341): 3.86e-10: 62.8: 13.40
+	Sc
		715320 SPT7_YEAST (223-610): 3.64e-27: 122: 12.08		TAF5_YEAST (15-267): 2.96e-38: 146: 14.77
+	Sc
		863629 GCN5_YEAST (140-462): 1.42e-41: 161: 16.37		COPA_YEAST (131-323): 1.27e-23: 104: 16.81
+	Sc
		784417 GCN5_YEAST (140-462): 1.42e-41: 161: 16.37		COPB2_YEAST (15-314): 1.99e-22: 100: 14.47
+	Hs
		1074790 BRDT_HUMAN (26-339): 2.9e-26: 119: 19.24		TAF5_HUMAN (178-328): 1.2e-21: 98: 18.42
+	Mm
		903669 KMT2C_MOUSE (495-1183): 4.41e-22: 106: 13.55		WDR5_MOUSE (247-341): 5.14e-19: 88.2: 19.79
+	Hs
		903409 KAT2B_HUMAN (327-456): 5.61e-22: 105: 26.92		WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79
+	Hs
		903408 KAT2A_HUMAN (327-456): 1.76e-20: 100: 26.15		WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79
+	Dm
		1358857 Q9VTZ1_DROME (336-457): 5.41e-22: 105: 30.89		WDS_DROME (3-110): 6.27e-10: 61.6: 8.48