HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: ANDR (P10275)
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
Gene: AR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007267 - cell-cell signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 920
+	Hs
		473353 HCK_HUMAN (1-127): 5.73e-42: 146: 20.30		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		519814 ABL2_HUMAN (1-127): 1.86e-40: 144: 27.48		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		439917 LCK_HUMAN (1-125): 8.6e-41: 143: 19.08		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		362134 ABL1_HUMAN (1-127): 1.01e-39: 142: 26.72		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		462956 YES_HUMAN (1-127): 5.29e-40: 141: 19.40		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		463293 LYN_HUMAN (1-125): 1.58e-39: 139: 19.85		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		519699 SRC_HUMAN (1-127): 1.8e-38: 137: 20.90		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		486651 FGR_HUMAN (1-126): 9.13e-38: 135: 20.30		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		519856 BLK_HUMAN (1-125): 9.83e-38: 135: 18.46		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		395341 YES_HUMAN (1-127): 5.29e-40: 141: 19.40		ESR1_HUMAN (378-904): 7.63e-136: 420: 22.20
+	Hs
		395400 SRC_HUMAN (1-127): 1.8e-38: 137: 20.90		ESR1_HUMAN (378-904): 7.63e-136: 420: 22.20
+	Rn
		439610 SRC_RAT (1-127): 1.35e-38: 137: 20.90		ESR1_RAT (378-904): 2.2e-130: 406: 20.94
+	Mm
		431322 SRC_MOUSE (1-127): 1.81e-38: 137: 20.90		ESR1_MOUSE (378-904): 2.51e-129: 403: 21.30
+	Hs
		403734 LCK_HUMAN (1-125): 8.6e-41: 143: 19.08		GCR_HUMAN (444-920): 1.2e-117: 378: 40.85
+	Hs
		403785 SRC_HUMAN (1-127): 1.8e-38: 137: 20.90		GCR_HUMAN (444-920): 1.2e-117: 378: 40.85
+	Hs
		557079 SRC_HUMAN (1-127): 1.8e-38: 137: 20.90		RXRA_HUMAN (392-902): 7.08e-120: 374: 19.84
+	Hs
		463183 YES_HUMAN (1-127): 5.29e-40: 141: 19.40		ESR2_HUMAN (435-912): 2.49e-116: 367: 21.51
+	Hs
		557411 SRC_HUMAN (1-127): 1.8e-38: 137: 20.90		ESR2_HUMAN (435-912): 2.49e-116: 367: 21.51
+	Hs
		442861 SRC_HUMAN (1-127): 1.8e-38: 137: 20.90		PRGR_HUMAN (469-920): 4.73e-106: 352: 45.73
+	Hs
		520501 SRC_HUMAN (1-127): 1.8e-38: 137: 20.90		RARA_HUMAN (460-902): 8.61e-110: 348: 19.87