HitPredict

Interactor 1: TP4A3 (O75365)
Protein tyrosine phosphatase type IVA 3 (EC 3.1.3.48) (PRL-R) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3)
Gene: PTP4A3

Interactor 2: GCN1 (Q92616)
Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1)
Gene: GCN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	17353931
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 173 Hs			1 2671
+	Hs
		1167728 TPTE2_HUMAN (6-168): 1.11e-42: 150: 15.85		GCN1_HUMAN (1-2671): 0: 2129: 100.00
+	Hs
		879832 TPTE_HUMAN (6-168): 3.19e-40: 144: 15.30		GCN1_HUMAN (1-2671): 0: 2129: 100.00
+	Hs
		985191 DUS2_HUMAN (2-154): 7.14e-31: 115: 18.71		GCN1_HUMAN (1-2671): 0: 2129: 100.00
+	Sp
		1013477 FLP1_SCHPO (3-160): 6.58e-39: 140: 21.97		GCN1_SCHPO (22-2662): 0: 1272: 27.76
+	Sc
		707911 CDC14_YEAST (11-169): 1.4e-37: 137: 22.73		GCN1_YEAST (593-2662): 0: 955: 30.30
+	Sc
		866890 CDC14_YEAST (11-169): 1.4e-37: 137: 22.73		EF3B_YEAST (1372-1700): 5.42e-91: 324: 27.38
+	Dm
		1181090 Q7KMQ6_DROME (5-152): 5.14e-41: 145: 21.82		CAND1_DROME (1333-2593): 1.83e-54: 212: 13.27
+	Hs
		127228 PTEN_HUMAN (5-163): 2.34e-41: 144: 18.86		IPO5_HUMAN (1381-2409): 4.59e-37: 155: 12.18
+	Hs
		56512 PTPC1_HUMAN (2-171): 8.66e-36: 133: 20.73		2AAB_HUMAN (2265-2670): 2.67e-36: 149: 14.67
+	Hs
		127251 DUS2_HUMAN (2-154): 7.14e-31: 115: 18.71		IPO5_HUMAN (1381-2409): 4.59e-37: 155: 12.18
+	Hs
		890725 PTEN_HUMAN (5-163): 2.34e-41: 144: 18.86		CAND1_HUMAN (1460-2587): 2.11e-22: 108: 13.92
+	Mm
		139429 PTEN_MOUSE (5-163): 2.46e-41: 144: 18.86		CAND1_MOUSE (1460-2587): 3.03e-22: 107: 13.61
+	Hs
		260568 TP4A3_HUMAN (1-173): 7.13e-57: 177: 100.00		ECM29_HUMAN (1769-2544): 4.52e-09: 64.6: 12.24
+	Hs
		672165 TENS2_HUMAN (4-168): 8.07e-39: 142: 13.74		2AAA_HUMAN (959-1405): 1.51e-19: 97.8: 12.22
+	Sp
		1350777 FLP1_SCHPO (3-160): 6.58e-39: 140: 21.97		2AAA_SCHPO (2261-2670): 1.63e-19: 97.4: 13.04
+	Hs
		56511 PTPC1_HUMAN (2-171): 8.66e-36: 133: 20.73		2AAA_HUMAN (959-1405): 1.51e-19: 97.8: 12.22
+	Hs
		253731 AUXI_HUMAN (9-151): 2.72e-33: 126: 15.48		2AAA_HUMAN (959-1405): 1.51e-19: 97.8: 12.22
+	Hs
		672262 DUS9_HUMAN (18-168): 1.2e-32: 121: 19.36		2AAA_HUMAN (959-1405): 1.51e-19: 97.8: 12.22
+	Hs
		1047843 CC14A_HUMAN (5-169): 4.17e-36: 133: 23.78		CKAP5_HUMAN (953-1968): 8.99e-11: 70.1: 10.33
+	Hs
		985181 DUS2_HUMAN (2-154): 7.14e-31: 115: 18.71		ECM29_HUMAN (1769-2544): 4.52e-09: 64.6: 12.24