HitPredict

Interactor 1: OPHN1 (O60890)
Oligophrenin-1
Gene: OPHN1

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9582072
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGAP
Common GO terms	GO:0030036 - actin cytoskeleton organization GO:0034329 - cell junction assembly GO:0043197 - dendritic spine GO:0045198 - establishment of epithelial cell apical/basal polarity GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 802 Hs			1 193
+	Hs
		260707 OPHN1_HUMAN (1-802): 0: 658: 100.00		RAC1_HUMAN (1-193): 7e-79: 235: 57.22
+	Hs
		260705 OPHN1_HUMAN (1-802): 0: 658: 100.00		CDC42_HUMAN (1-193): 4.17e-76: 228: 52.33
+	Hs
		65907 RHG42_HUMAN (1-797): 0: 565: 50.24		RAC1_HUMAN (1-193): 7e-79: 235: 57.22
+	Hs
		65899 RHG42_HUMAN (1-797): 0: 565: 50.24		RAC2_HUMAN (1-193): 2.82e-75: 226: 53.61
+	Hs
		65906 RHG42_HUMAN (1-797): 0: 565: 50.24		RAC3_HUMAN (1-179): 3.87e-73: 220: 57.54
+	Hs
		962632 RHG26_HUMAN (1-645): 0: 541: 50.92		RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00
+	Hs
		49960 RHG10_HUMAN (1-718): 3.83e-178: 533: 45.08		RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00
+	Hs
		955753 RHG26_HUMAN (1-645): 0: 541: 50.92		CDC42_HUMAN (1-193): 4.17e-76: 228: 52.33
+	Hs
		49959 RHG10_HUMAN (1-718): 3.83e-178: 533: 45.08		CDC42_HUMAN (1-193): 4.17e-76: 228: 52.33
+	Dm
		828044 RHGF_DROME (2-798): 1.18e-151: 471: 30.55		RAC1_DROME (1-193): 1.51e-76: 229: 54.12
+	Hs
		269537 SRGP2_HUMAN (7-796): 5.56e-113: 370: 15.43		RAC1_HUMAN (1-193): 7e-79: 235: 57.22
+	Mm
		1362439 SRGP1_MOUSE (6-793): 2.68e-110: 363: 15.51		RHOA_MOUSE (1-193): 2.21e-80: 238: 99.48
+	Hs
		212765 SRGP3_HUMAN (6-795): 4.88e-108: 357: 14.92		RAC1_HUMAN (1-193): 7e-79: 235: 57.22
+	Hs
		962215 SRGP1_HUMAN (6-793): 2.42e-107: 355: 14.78		RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00
+	Mm
		953811 SRGP1_MOUSE (6-793): 2.68e-110: 363: 15.51		CDC42_MOUSE (1-193): 4.17e-76: 228: 52.33
+	Hs
		269533 SRGP2_HUMAN (7-796): 5.56e-113: 370: 15.43		RAC3_HUMAN (1-179): 3.87e-73: 220: 57.54
+	Hs
		962018 MYO9B_HUMAN (4-766): 9.6e-104: 353: 16.67		RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00
+	Hs
		988485 SRGP1_HUMAN (6-793): 2.42e-107: 355: 14.78		RAC1_HUMAN (1-193): 7e-79: 235: 57.22
+	Hs
		466239 MYO9B_HUMAN (4-766): 9.6e-104: 353: 16.67		RHOC_HUMAN (1-193): 1.75e-77: 231: 91.71
+	Hs
		955132 MYO9B_HUMAN (4-766): 9.6e-104: 353: 16.67		CDC42_HUMAN (1-193): 4.17e-76: 228: 52.33