HitPredict

Interactor 1: O62530 (O62530)
Adaptor protein complex 2, mu subunit, isoform A (Adaptor protein complex 2, mu subunit, isoform B) (Adaptor protein complex 2, mu subunit, isoform C) (Clathrin-associated adaptor complex AP-2 medium chain) (Clathrin-associated protein) (SD05403p)
Gene: AP-2mu

Interactor 2: Q9VDC3 (Q9VDC3)
AP complex subunit sigma
Gene: AP-2sigma

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Adap_comp_sub~Clat_adaptor_s, Clat_adaptor_s~Clat_adaptor_s
Common GO terms	GO:0006886 - intracellular protein transport GO:0006897 - endocytosis GO:0030122 - AP-2 adaptor complex GO:0035615 - clathrin adaptor activity GO:0072583 - clathrin-dependent endocytosis
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 437 Dm			1 142
+	Hs
		965420 AP2M1_HUMAN (1-437): 2.32e-175: 499: 86.79		AP1S1_HUMAN (1-142): 1.96e-51: 162: 45.07
+	Hs
		940566 AP2M1_HUMAN (1-437): 2.32e-175: 499: 86.79		AP1S2_HUMAN (2-142): 4.12e-51: 161: 46.81
+	Hs
		1386676 AP2M1_HUMAN (1-437): 2.32e-175: 499: 86.79		AP1S3_HUMAN (1-142): 1.18e-49: 157: 43.66
+	Hs
		965423 AP1M1_HUMAN (2-436): 7.86e-174: 494: 39.59		AP1S1_HUMAN (1-142): 1.96e-51: 162: 45.07
+	Hs
		940571 AP1M1_HUMAN (2-436): 7.86e-174: 494: 39.59		AP1S2_HUMAN (2-142): 4.12e-51: 161: 46.81
+	Hs
		1399536 AP1M1_HUMAN (2-436): 7.86e-174: 494: 39.59		AP1S3_HUMAN (1-142): 1.18e-49: 157: 43.66
+	Hs
		922601 AP2M1_HUMAN (1-437): 2.32e-175: 499: 86.79		AP2S1_HUMAN (1-142): 4.87e-46: 148: 95.78
+	Mm
		977888 AP2M1_MOUSE (1-437): 2.32e-175: 499: 86.79		AP2S1_MOUSE (1-142): 4.87e-46: 148: 95.78
+	Hs
		1417339 AP1M1_HUMAN (2-436): 7.86e-174: 494: 39.59		AP1M2_HUMAN (2-142): 2.74e-44: 151: 20.14
+	Mm
		1015347 AP2M1_MOUSE (1-437): 2.32e-175: 499: 86.79		AP2M1_MOUSE (1-138): 1.51e-41: 144: 15.22
+	Hs
		1386658 AP2M1_HUMAN (1-437): 2.32e-175: 499: 86.79		AP2M1_HUMAN (1-138): 1.51e-41: 144: 15.22
+	Hs
		965429 AP1M2_HUMAN (2-436): 3.49e-167: 478: 37.53		AP1S1_HUMAN (1-142): 1.96e-51: 162: 45.07
+	Hs
		940580 AP1M2_HUMAN (2-436): 3.49e-167: 478: 37.53		AP1S2_HUMAN (2-142): 4.12e-51: 161: 46.81
+	Hs
		1399540 AP1M2_HUMAN (2-436): 3.49e-167: 478: 37.53		AP1S3_HUMAN (1-142): 1.18e-49: 157: 43.66
+	At
		199760 AP2M_ARATH (2-437): 1.73e-161: 464: 46.62		AP2S_ARATH (1-142): 1.24e-44: 144: 59.86
+	Sc
		1027311 AP1M1_YEAST (1-436): 1.6e-148: 432: 34.66		AP1M1_YEAST (1-139): 7.94e-42: 146: 17.14
+	Sc
		763214 AP1M1_YEAST (1-436): 1.6e-148: 432: 34.66		AP1S1_YEAST (2-142): 2.75e-42: 139: 40.56
+	Hs
		1364946 AP3M1_HUMAN (1-436): 2.27e-124: 369: 24.44		AP3S1_HUMAN (1-142): 4.28e-51: 162: 40.54
+	Hs
		948111 AP3M1_HUMAN (1-436): 2.27e-124: 369: 24.44		AP3S2_HUMAN (1-142): 3.11e-49: 158: 37.84