HitPredict

Interactor 1: GRK6 (O70293)
G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)
Gene: GRK6

Interactor 2: OPSD (P15409)
Rhodopsin
Gene: Rho

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	10446210
Identification Methods	protein kinase assay
Interaction Type	phosphorylation reaction

Property	Details
Interacting Pfam domains	7tm_1~Pkinase
Common GO terms	GO:0016020 - membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 576 Mm			1 348
+	Hs
		458319 GRK6_HUMAN (1-576): 0: 576: 96.70		ADRB2_HUMAN (1-345): 1.21e-71: 230: 17.52
+	Hs
		465754 GRK5_HUMAN (1-560): 2.22e-176: 513: 72.50		OPSD_HUMAN (1-348): 4.05e-80: 249: 94.83
+	Hs
		458298 GRK5_HUMAN (1-560): 2.22e-176: 513: 72.50		ADRB2_HUMAN (1-345): 1.21e-71: 230: 17.52
+	Hs
		669218 GRK5_HUMAN (1-560): 2.22e-176: 513: 72.50		NK1R_HUMAN (13-340): 1.34e-70: 227: 22.69
+	Hs
		458295 GRK4_HUMAN (1-575): 9.8e-175: 508: 64.99		ADRB2_HUMAN (1-345): 1.21e-71: 230: 17.52
+	Bt
		388112 GRK1_BOVIN (3-551): 3.63e-157: 462: 46.03		OPSD_BOVIN (1-348): 7.35e-87: 267: 93.39
+	Hs
		720646 GRK5_HUMAN (1-560): 2.22e-176: 513: 72.50		AGTR1_HUMAN (32-348): 1.24e-66: 215: 19.94
+	Hs
		465756 GRK1_HUMAN (3-537): 7.24e-154: 454: 47.59		OPSD_HUMAN (1-348): 4.05e-80: 249: 94.83
+	Hs
		458413 GRK1_HUMAN (3-537): 7.24e-154: 454: 47.59		ADRB2_HUMAN (1-345): 1.21e-71: 230: 17.52
+	Hs
		465750 ARBK1_HUMAN (2-518): 3.16e-143: 431: 37.69		OPSD_HUMAN (1-348): 4.05e-80: 249: 94.83
+	Hs
		458303 ARBK2_HUMAN (2-518): 5.56e-145: 436: 38.07		ADRB2_HUMAN (1-345): 1.21e-71: 230: 17.52
+	Hs
		458283 ARBK1_HUMAN (2-518): 3.16e-143: 431: 37.69		ADRB2_HUMAN (1-345): 1.21e-71: 230: 17.52
+	Hs
		669106 ARBK1_HUMAN (2-518): 3.16e-143: 431: 37.69		AGTR1_HUMAN (32-348): 1.24e-66: 215: 19.94
+	Hs
		669126 ARBK1_HUMAN (2-518): 3.16e-143: 431: 37.69		GPR17_HUMAN (34-325): 4.1e-18: 86.3: 23.26