HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: NONO (Q15233)
Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit)
Gene: NONO

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24457600
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005694 - chromosome GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 441 Hs			1 471
+	Mm
		1265413 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		NONO_MOUSE (1-471): 4.7e-94: 294: 98.31
+	Hs
		268193 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		PSPC1_HUMAN (20-470): 2.17e-67: 226: 58.41
+	Mm
		1246845 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		PSPC1_MOUSE (20-470): 5.48e-67: 225: 57.40
+	Mm
		665768 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		PABP1_MOUSE (66-459): 9.31e-65: 222: 14.89
+	Mm
		1257672 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		SFPQ_MOUSE (23-471): 7.21e-54: 193: 55.72
+	Hs
		267890 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		SFPQ_HUMAN (45-471): 3.15e-53: 192: 56.92
+	Hs
		268115 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		ELAV1_HUMAN (68-205): 7.38e-47: 166: 27.82
+	Mm
		936695 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		ELAV1_MOUSE (68-205): 2.05e-46: 165: 28.48
+	Hs
		1069762 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		NONO_HUMAN (1-471): 1.15e-97: 303: 100.00
+	Mm
		1208008 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		RBM4_MOUSE (75-182): 5.42e-09: 59.7: 35.71
+	Hs
		268262 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		RBM4_HUMAN (75-182): 7.64e-09: 59.3: 35.71
+	Hs
		1263497 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		PSPC1_HUMAN (20-470): 2.17e-67: 226: 58.41
+	Hs
		903196 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		PABP4_HUMAN (66-467): 1.55e-70: 237: 15.42
+	Hs
		613543 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		SFPQ_HUMAN (45-471): 3.15e-53: 192: 56.92
+	Hs
		516438 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		PABP1_HUMAN (66-459): 7.11e-65: 222: 14.89
+	Hs
		613398 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		SFPQ_HUMAN (45-471): 3.15e-53: 192: 56.92
+	Hs
		1077517 NLE1_HUMAN (4-124): 2.95e-18: 88.8: 9.09		ELAV1_HUMAN (68-205): 7.38e-47: 166: 27.82
+	Hs
		1222300 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		RAVR1_HUMAN (76-221): 8.34e-12: 69.4: 24.70
+	Hs
		1308786 NLE1_HUMAN (4-124): 2.95e-18: 88.8: 9.09		RBM4B_HUMAN (75-182): 7.1e-09: 59.3: 35.71
+	Hs
		1314629 NLE1_HUMAN (4-124): 2.95e-18: 88.8: 9.09		RBM4_HUMAN (75-182): 7.64e-09: 59.3: 35.71