HitPredict

Interactor 1: SIN3B (O75182)
Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b)
Gene: SIN3B

Interactor 2: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	30415952, 25452129, 24951594
Identification Methods	proximity labelling technology, affinity chromatography technology, anti bait coimmunoprecipitation, chromatin immunoprecipitation assay
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1162 Hs			1 454
+	Hs
		274297 SIN3B_HUMAN (1-1162): 0: 1451: 100.00		MXI1_HUMAN (321-450): 2.57e-29: 116: 27.69
+	Mm
		896181 SIN3B_MOUSE (25-1162): 0: 1345: 87.28		MAD1_MOUSE (320-454): 3.02e-30: 118: 23.70
+	Mm
		896218 SIN3B_MOUSE (25-1162): 0: 1345: 87.28		MXI1_MOUSE (321-450): 1.28e-29: 117: 27.69
+	Mm
		148318 SIN3B_MOUSE (25-1162): 0: 1345: 87.28		MNT_MOUSE (244-452): 7.44e-25: 109: 20.83
+	Rn
		64501 A6K9M6_RAT (25-289): 3.96e-91: 296: 87.93		MYC_RAT (1-454): 1.14e-113: 343: 88.57
+	Hs
		372919 SIN3A_HUMAN (78-366): 2.04e-15: 83.8: 15.60		MYC_HUMAN (1-454): 4.53e-121: 362: 100.00
+	Ce
		63504 SIN3_CAEEL (7-156): 2.9e-34: 145: 32.00		MXL3_CAEEL (367-439): 1.74e-20: 92.1: 32.88
+	Mm
		1221144 SIN3A_MOUSE (78-366): 2.11e-15: 83.8: 15.60		SRBP1_MOUSE (172-453): 7.23e-35: 140: 16.61
+	Hs
		787894 SIN3A_HUMAN (78-366): 2.04e-15: 83.8: 15.60		SRBP1_HUMAN (95-453): 7.2e-33: 134: 16.19
+	Dm
		1216762 Q5U0Y0_DROME (113-262): 8.79e-24: 111: 36.31		X2JDM5_DROME (358-449): 1.1e-20: 97.1: 29.03
+	Mm
		896180 SIN3A_MOUSE (78-366): 2.11e-15: 83.8: 15.60		MAD1_MOUSE (320-454): 3.02e-30: 118: 23.70
+	Mm
		896217 SIN3A_MOUSE (78-366): 2.11e-15: 83.8: 15.60		MXI1_MOUSE (321-450): 1.28e-29: 117: 27.69
+	Hs
		896207 SIN3A_HUMAN (78-366): 2.04e-15: 83.8: 15.60		MXI1_HUMAN (321-450): 2.57e-29: 116: 27.69
+	Mm
		148317 SIN3A_MOUSE (78-366): 2.11e-15: 83.8: 15.60		MNT_MOUSE (244-452): 7.44e-25: 109: 20.83
+	Mm
		1221137 SIN3A_MOUSE (78-366): 2.11e-15: 83.8: 15.60		Q91VN7_MOUSE (320-449): 4.31e-26: 107: 23.85
+	Hs
		1403005 SIN3A_HUMAN (78-366): 2.04e-15: 83.8: 15.60		MNT_HUMAN (274-452): 2.6e-24: 107: 21.11
+	Hs
		1050746 SIN3A_HUMAN (78-366): 2.04e-15: 83.8: 15.60		MAD1_HUMAN (320-453): 2.21e-25: 105: 19.40
+	Hs
		1403010 SIN3A_HUMAN (78-366): 2.04e-15: 83.8: 15.60		MAD3_HUMAN (320-450): 1.26e-25: 105: 26.72
+	Hs
		959638 SIN3A_HUMAN (78-366): 2.04e-15: 83.8: 15.60		MAX_HUMAN (354-454): 1.4e-24: 101: 32.67