HitPredict

Interactor 1: VAMP4 (O75379)
Vesicle-associated membrane protein 4 (VAMP-4)
Gene: VAMP4

Interactor 2: SNAA (P54920)
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha)
Gene: NAPA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.950

Property	Details
Experiments	28514442, 33961781, 35271311, 31839598, 30833792, 40437099
Identification Methods	affinity chromatography technology, cross-linking study, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNAP~Synaptobrevin
Common GO terms	GO:0098978 - glutamatergic synapse
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 141 Hs			1 295
+	Hs
		278559 VAMP4_HUMAN (1-120): 6.5e-39: 129: 100.00		SNAB_HUMAN (1-292): 6.05e-113: 329: 84.25
+	Hs
		907987 VAMP7_HUMAN (15-139): 5e-34: 119: 27.20		SNAA_HUMAN (1-295): 2.14e-113: 330: 100.00
+	Dm
		1171606 Q7JYX5_DROME (15-138): 3.31e-37: 127: 27.42		SNAP_DROME (5-295): 7.88e-105: 308: 61.51
+	Hs
		933010 VAMP3_HUMAN (47-119): 1.51e-26: 97: 41.10		SNAA_HUMAN (1-295): 2.14e-113: 330: 100.00
+	Hs
		933050 VAMP8_HUMAN (41-120): 1.92e-26: 97: 27.50		SNAA_HUMAN (1-295): 2.14e-113: 330: 100.00
+	Hs
		932991 VAMP2_HUMAN (46-122): 4.03e-26: 96.7: 35.07		SNAA_HUMAN (1-295): 2.14e-113: 330: 100.00
+	Mm
		704313 VAMP2_MOUSE (46-122): 4.03e-26: 96.7: 35.07		SNAB_MOUSE (1-292): 6.05e-113: 329: 84.25
+	Zm
		31396 A0A1D6KH00_MAIZE (6-138): 1.2e-43: 153: 27.82		A0A1D6PZ82_MAIZE (5-272): 3.98e-89: 271: 36.80
+	Dm
		614895 SYB_DROME (46-135): 3.2e-31: 110: 30.00		SNAP_DROME (5-295): 7.88e-105: 308: 61.51
+	Sc
		743495 NYV1_YEAST (11-138): 1.49e-27: 103: 24.64		SEC17_YEAST (8-294): 4.65e-88: 266: 34.48
+	Sc
		724257 SNC1_YEAST (42-119): 9.7e-24: 90.5: 30.77		SEC17_YEAST (8-294): 4.65e-88: 266: 34.48
+	Hs
		278549 VAMP4_HUMAN (1-120): 6.5e-39: 129: 100.00		SNAG_HUMAN (4-265): 6.78e-68: 215: 23.40
+	Hs
		908047 VAMP7_HUMAN (15-139): 5e-34: 119: 27.20		SNAG_HUMAN (4-265): 6.78e-68: 215: 23.40
+	Dm
		1263454 Q7JYX5_DROME (15-138): 3.31e-37: 127: 27.42		Q9U6R9_DROME (4-265): 3.86e-58: 190: 18.49
+	Hs
		1154723 VAMP3_HUMAN (47-119): 1.51e-26: 97: 41.10		SNAG_HUMAN (4-265): 6.78e-68: 215: 23.40
+	Hs
		1407039 VAMP8_HUMAN (41-120): 1.92e-26: 97: 27.50		SNAG_HUMAN (4-265): 6.78e-68: 215: 23.40
+	Hs
		989376 VAMP2_HUMAN (46-122): 4.03e-26: 96.7: 35.07		SNAG_HUMAN (4-265): 6.78e-68: 215: 23.40
+	Dm
		1263460 Q7JYX5_DROME (15-138): 3.31e-37: 127: 27.42		Q9VH25_DROME (18-265): 1.81e-53: 177: 17.53
+	Dm
		614932 SYB_DROME (46-135): 3.2e-31: 110: 30.00		Q9U6R9_DROME (4-265): 3.86e-58: 190: 18.49