HitPredict

Interactor 1: SYB (P18489)
Synaptobrevin
Gene: SYB

Interactor 2: SNAP (Q23983)
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein)
Gene: alphaSnap

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNAP~Synaptobrevin
Common GO terms	GO:0000149 - SNARE binding GO:0007269 - neurotransmitter secretion GO:0019905 - syntaxin binding GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 152 Dm			1 292
+	Dm
		1171606 Q7JYX5_DROME (4-127): 3.99e-39: 133: 14.29		SNAP_DROME (1-292): 3.39e-109: 320: 100.00
+	Dm
		121790 M9PGI6_DROME (3-128): 8.27e-37: 127: 16.67		SNAP_DROME (1-292): 3.39e-109: 320: 100.00
+	Dm
		305557 O77434_DROME (3-128): 9.32e-37: 127: 16.67		SNAP_DROME (1-292): 3.39e-109: 320: 100.00
+	Hs
		280163 SC22B_HUMAN (3-131): 5.15e-39: 132: 18.32		SNAA_HUMAN (17-290): 2.9e-106: 312: 61.68
+	Hs
		192222 YKT6_HUMAN (1-101): 3.96e-33: 117: 20.79		SNAA_HUMAN (17-290): 2.9e-106: 312: 61.68
+	Hs
		907987 VAMP7_HUMAN (3-112): 4.71e-31: 112: 22.32		SNAA_HUMAN (17-290): 2.9e-106: 312: 61.68
+	Hs
		933010 VAMP3_HUMAN (34-115): 1.55e-28: 102: 60.98		SNAA_HUMAN (17-290): 2.9e-106: 312: 61.68
+	Hs
		933050 VAMP8_HUMAN (40-115): 3.09e-28: 102: 30.26		SNAA_HUMAN (17-290): 2.9e-106: 312: 61.68
+	Zm
		31396 A0A1D6KH00_MAIZE (3-127): 7.01e-36: 132: 27.13		A0A1D6PZ82_MAIZE (1-270): 7.63e-93: 280: 36.16
+	Sc
		646219 SEC22_YEAST (3-129): 6.21e-37: 127: 19.38		SEC17_YEAST (6-290): 1.29e-86: 262: 31.94
+	Dm
		614932 SYB_DROME (1-152): 1.12e-53: 168: 100.00		Q9U6R9_DROME (4-263): 7.97e-58: 189: 19.01
+	Hs
		280315 SC22B_HUMAN (3-131): 5.15e-39: 132: 18.32		SNAG_HUMAN (7-249): 4.08e-67: 213: 19.92
+	Hs
		192305 YKT6_HUMAN (1-101): 3.96e-33: 117: 20.79		SNAG_HUMAN (7-249): 4.08e-67: 213: 19.92
+	Hs
		908047 VAMP7_HUMAN (3-112): 4.71e-31: 112: 22.32		SNAG_HUMAN (7-249): 4.08e-67: 213: 19.92
+	Dm
		1263454 Q7JYX5_DROME (4-127): 3.99e-39: 133: 14.29		Q9U6R9_DROME (4-263): 7.97e-58: 189: 19.01
+	Dm
		121810 M9PGI6_DROME (3-128): 8.27e-37: 127: 16.67		Q9U6R9_DROME (4-263): 7.97e-58: 189: 19.01
+	Dm
		1263460 Q7JYX5_DROME (4-127): 3.99e-39: 133: 14.29		Q9VH25_DROME (16-263): 7.6e-56: 183: 18.73
+	Dm
		305578 O77434_DROME (3-128): 9.32e-37: 127: 16.67		Q9U6R9_DROME (4-263): 7.97e-58: 189: 19.01
+	Hs
		1407039 VAMP8_HUMAN (40-115): 3.09e-28: 102: 30.26		SNAG_HUMAN (7-249): 4.08e-67: 213: 19.92
+	Dm
		121816 M9PGI6_DROME (3-128): 8.27e-37: 127: 16.67		Q9VH25_DROME (16-263): 7.6e-56: 183: 18.73