Interactor 1: RNF8 (O76064)
E3 ubiquitin-protein ligase RNF8 (hRNF8) (EC 2.3.2.27) (RING finger protein 8) (RING-type E3 ubiquitin transferase RNF8)
Gene: RNF8
Interactor 2: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.91 | 1.00 | 0.956 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25512560, 18001824, 18006705, 28943310, 18001825, 24240613 |
| Identification Methods | affinity chromatography technology, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, isothermal titration calorimetry |
| Interaction Type | physical association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | FHA~FHA |
| Common GO terms | GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response GO:0035861 - site of double-strand break |
| Homologous interactions | 11 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
