HitPredict

Interactor 1: RNF8 (O76064)
E3 ubiquitin-protein ligase RNF8 (hRNF8) (EC 2.3.2.27) (RING finger protein 8) (RING-type E3 ubiquitin transferase RNF8)
Gene: RNF8

Interactor 2: UB2E3 (Q969T4)
Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3)
Gene: UBE2E3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.680

Property	Details
Experiments	11322894
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0070534 - protein K63-linked ubiquitination GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 485 Hs			1 207
+	Hs
		282716 RNF8_HUMAN (1-485): 0: 523: 100.00		UB2E2_HUMAN (1-207): 5.59e-89: 261: 85.02
+	Hs
		282607 RNF8_HUMAN (1-485): 0: 523: 100.00		UB2D2_HUMAN (61-206): 2.03e-82: 242: 65.07
+	Hs
		282581 RNF8_HUMAN (1-485): 0: 523: 100.00		UB2D1_HUMAN (61-206): 9.93e-82: 241: 61.64
+	Hs
		282595 RNF8_HUMAN (1-485): 0: 523: 100.00		UB2D3_HUMAN (61-206): 1.1e-80: 238: 64.38
+	Hs
		282582 RNF8_HUMAN (1-485): 0: 523: 100.00		UB2E1_HUMAN (35-207): 2.62e-79: 236: 87.36
+	Hs
		282596 RNF8_HUMAN (1-485): 0: 523: 100.00		UBE2N_HUMAN (59-206): 3.58e-69: 209: 45.27
+	Mm
		896589 RNF8_MOUSE (1-484): 3.26e-177: 508: 71.05		UBE2N_MOUSE (59-206): 3.58e-69: 209: 45.27
+	Hs
		1282325 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UB2E3_HUMAN (1-207): 5.71e-90: 264: 100.00
+	Hs
		1290120 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UB2E2_HUMAN (1-207): 5.59e-89: 261: 85.02
+	Hs
		1290127 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UB2D4_HUMAN (61-206): 1.19e-82: 243: 63.01
+	Hs
		919820 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UB2D2_HUMAN (61-206): 2.03e-82: 242: 65.07
+	Hs
		849404 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UB2D1_HUMAN (61-206): 9.93e-82: 241: 61.64
+	Hs
		895874 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UB2D3_HUMAN (61-206): 1.1e-80: 238: 64.38
+	Hs
		851866 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UB2E1_HUMAN (35-207): 2.62e-79: 236: 87.36
+	Mm
		896587 CHFR_MOUSE (37-474): 4.95e-91: 292: 19.68		UBE2N_MOUSE (59-206): 3.58e-69: 209: 45.27
+	Hs
		896515 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UBE2N_HUMAN (59-206): 3.58e-69: 209: 45.27
+	Hs
		849415 UHRF2_HUMAN (204-472): 7.12e-40: 155: 13.07		UB2D1_HUMAN (61-206): 9.93e-82: 241: 61.64
+	Hs
		895886 UHRF2_HUMAN (204-472): 7.12e-40: 155: 13.07		UB2D3_HUMAN (61-206): 1.1e-80: 238: 64.38
+	At
		639387 BRE1B_ARATH (137-446): 1.13e-41: 160: 17.74		UBC1_ARATH (59-204): 3.49e-70: 212: 38.36
+	At
		790157 BRE1B_ARATH (137-446): 1.13e-41: 160: 17.74		UBC2_ARATH (59-204): 2.57e-70: 212: 37.67