HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: SMCA1 (P28370)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 (SMARCA1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A1) (EC 3.6.4.-) (Global transcription activator SNF2L1) (Nucleosome-remodeling factor subunit SNF2L) (SNF2L) (SNF2 related chromatin remodeling ATPase 1)
Gene: SMARCA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	24457600, 24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Helicase_C~WD40, SNF2-rel_dom~WD40
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 441 Hs			1 1042
+	Mm
		1244292 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		SMCA1_MOUSE (1-1042): 0: 1051: 95.80
+	Mm
		1362466 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		SMCA5_MOUSE (73-1037): 0: 998: 86.01
+	Hs
		243487 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		SMCA5_HUMAN (32-1037): 0: 995: 82.90
+	Hs
		703359 FBXW7_HUMAN (219-439): 2.95e-26: 113: 15.32		SMCA1_HUMAN (1-1042): 0: 1036: 100.00
+	Hs
		703360 SNR40_HUMAN (298-441): 2.31e-21: 96.6: 14.29		SMCA1_HUMAN (1-1042): 0: 1036: 100.00
+	Mm
		59411 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		CHD7_MOUSE (3-1031): 0: 786: 26.81
+	Hs
		285243 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		CHD3_HUMAN (29-942): 0: 765: 29.55
+	Hs
		285283 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		CHD4_HUMAN (32-942): 0: 758: 28.87
+	Mm
		1243972 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		CHD4_MOUSE (32-942): 0: 757: 28.87
+	Hs
		160150 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		CHD2_HUMAN (14-1040): 0: 703: 29.42
+	Hs
		285151 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		SMCA4_HUMAN (60-851): 0: 691: 33.64
+	Hs
		1088581 NLE1_HUMAN (296-440): 9.08e-25: 108: 16.45		CHD3_HUMAN (29-942): 0: 765: 29.55
+	Hs
		1132879 FBXW7_HUMAN (219-439): 2.95e-26: 113: 15.32		CHD4_HUMAN (32-942): 0: 758: 28.87
+	Hs
		1350646 FBXW7_HUMAN (219-439): 2.95e-26: 113: 15.32		CHD6_HUMAN (1-1033): 0: 743: 27.20
+	Hs
		903450 FBXW7_HUMAN (219-439): 2.95e-26: 113: 15.32		SMCA4_HUMAN (60-851): 0: 691: 33.64
+	Hs
		903453 SNR40_HUMAN (298-441): 2.31e-21: 96.6: 14.29		SMCA4_HUMAN (60-851): 0: 691: 33.64
+	Hs
		160120 FBXW7_HUMAN (219-439): 2.95e-26: 113: 15.32		CHD1_HUMAN (5-1041): 0: 671: 28.96
+	Hs
		160123 SNR40_HUMAN (298-441): 2.31e-21: 96.6: 14.29		CHD1_HUMAN (5-1041): 0: 671: 28.96
+	Mm
		1189468 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		SMCA4_MOUSE (60-657): 7.51e-133: 441: 41.99
+	Hs
		285150 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		SMCA2_HUMAN (170-657): 6.55e-126: 421: 45.35