HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: SMCA4 (P51532)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1)
Gene: SMARCA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24457600
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Helicase_C~WD40, SNF2-rel_dom~WD40
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 441 Hs			1 1647
+	Mm
		1189468 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		SMCA4_MOUSE (1-1647): 0: 1050: 96.66
+	Hs
		285150 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		SMCA2_HUMAN (40-1647): 0: 958: 72.59
+	Hs
		903450 FBXW7_HUMAN (219-439): 2.95e-26: 113: 15.32		SMCA4_HUMAN (1-1647): 0: 1088: 100.00
+	Hs
		903453 SNR40_HUMAN (298-441): 2.31e-21: 96.6: 14.29		SMCA4_HUMAN (1-1647): 0: 1088: 100.00
+	Hs
		285095 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		SMCA1_HUMAN (639-1621): 0: 830: 29.20
+	Mm
		1244292 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		SMCA1_MOUSE (568-1621): 0: 826: 27.45
+	Hs
		243487 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		SMCA5_HUMAN (594-1622): 0: 815: 27.27
+	Mm
		1362466 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		SMCA5_MOUSE (599-1622): 0: 812: 27.12
+	Hs
		285243 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		CHD3_HUMAN (270-1647): 0: 733: 21.04
+	Hs
		285283 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		CHD4_HUMAN (394-1632): 0: 726: 21.98
+	Mm
		1243972 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		CHD4_MOUSE (394-1632): 0: 725: 21.98
+	Hs
		160150 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		CHD2_HUMAN (343-1449): 0: 687: 26.91
+	Hs
		703359 FBXW7_HUMAN (219-439): 2.95e-26: 113: 15.32		SMCA1_HUMAN (639-1621): 0: 830: 29.20
+	Hs
		703360 SNR40_HUMAN (298-441): 2.31e-21: 96.6: 14.29		SMCA1_HUMAN (639-1621): 0: 830: 29.20
+	Hs
		1088581 NLE1_HUMAN (296-440): 9.08e-25: 108: 16.45		CHD3_HUMAN (270-1647): 0: 733: 21.04
+	Hs
		1132879 FBXW7_HUMAN (219-439): 2.95e-26: 113: 15.32		CHD4_HUMAN (394-1632): 0: 726: 21.98
+	Hs
		1088500 SNR40_HUMAN (298-441): 2.31e-21: 96.6: 14.29		CHD3_HUMAN (270-1647): 0: 733: 21.04
+	Hs
		1350646 FBXW7_HUMAN (219-439): 2.95e-26: 113: 15.32		CHD6_HUMAN (363-1488): 0: 699: 23.85
+	Hs
		1380192 FBXW7_HUMAN (219-439): 2.95e-26: 113: 15.32		HELLS_HUMAN (683-1234): 1.22e-106: 362: 36.56
+	Mm
		59411 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		CHD7_MOUSE (53-755): 6.41e-16: 86.4: 10.21