HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: H31T (Q16695)
Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4)
Gene: H3-4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.666

Property	Details
Experiments	20974918
Identification Methods	unspecified method, x-ray crystallography
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	Histone~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 441 Hs			1 136
+	Hs
		285205 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		H31_HUMAN (1-136): 3.36e-62: 188: 97.06
+	Hs
		285216 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		H33_HUMAN (1-136): 1.86e-61: 186: 93.38
+	Dm
		381735 Q9VKD5_DROME (1-440): 5.53e-78: 251: 49.89		H3_DROME (1-136): 6e-61: 185: 96.32
+	Hs
		261420 TBL1X_HUMAN (25-441): 2.18e-71: 237: 11.74		H32_HUMAN (1-136): 6e-61: 185: 96.32
+	Hs
		998776 TBL1R_HUMAN (25-267): 1.29e-47: 172: 14.40		H31_HUMAN (1-136): 3.36e-62: 188: 97.06
+	Hs
		998532 DAW1_HUMAN (292-439): 3.76e-19: 90.8: 13.91		H31_HUMAN (1-136): 3.36e-62: 188: 97.06
+	Hs
		998350 TAF5_HUMAN (173-441): 4.82e-16: 82.5: 21.19		H31_HUMAN (1-136): 3.36e-62: 188: 97.06
+	Hs
		1149773 TAF5_HUMAN (173-441): 4.82e-16: 82.5: 21.19		H31T_HUMAN (1-136): 1.34e-61: 187: 100.00
+	Hs
		998682 THOC3_HUMAN (148-434): 3.99e-16: 81.3: 19.03		H31_HUMAN (1-136): 3.36e-62: 188: 97.06
+	Hs
		1016886 TAF5_HUMAN (173-441): 4.82e-16: 82.5: 21.19		H33_HUMAN (1-136): 1.86e-61: 186: 93.38
+	Sc
		779302 COPA_YEAST (9-295): 5.36e-29: 122: 11.15		CENPA_YEAST (18-134): 4.29e-43: 143: 53.33
+	Hs
		845310 LIS1_HUMAN (332-438): 1.47e-14: 76.9: 18.69		H31T_HUMAN (1-136): 1.34e-61: 187: 100.00
+	Hs
		964837 WDR5_HUMAN (335-440): 3.34e-14: 75.4: 15.09		H31_HUMAN (1-136): 3.36e-62: 188: 97.06
+	Hs
		964981 WDR5_HUMAN (335-440): 3.34e-14: 75.4: 15.09		H31T_HUMAN (1-136): 1.34e-61: 187: 100.00
+	Hs
		964848 WDR5_HUMAN (335-440): 3.34e-14: 75.4: 15.09		H33_HUMAN (1-136): 1.86e-61: 186: 93.38
+	Dm
		381700 ESC_DROME (23-226): 4.37e-10: 63.5: 8.10		H3_DROME (1-136): 6e-61: 185: 96.32
+	Hs
		209245 PRP4_HUMAN (332-437): 4.05e-09: 60.4: 15.79		H31_HUMAN (1-136): 3.36e-62: 188: 97.06
+	At
		235435 LUH_ARATH (365-439): 2.55e-09: 61.3: 20.00		H31_ARATH (1-136): 1.56e-60: 184: 94.12