HitPredict

Interactor 1: LRP6 (O75581)
Low-density lipoprotein receptor-related protein 6 (LRP-6)
Gene: LRP6

Interactor 2: KLK5 (Q9Y337)
Kallikrein-5 (EC 3.4.21.-) (Kallikrein-like protein 2) (KLK-L2) (Stratum corneum tryptic enzyme)
Gene: KLK5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FXa_inhibition~Trypsin, Ldl_recept_a~Trypsin
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1613 Hs			1 293
+	Hs
		287523 LRP6_HUMAN (1-1613): 0: 1777: 100.00		KLK2_HUMAN (55-292): 9.7e-99: 292: 41.20
+	Hs
		287608 LRP6_HUMAN (1-1613): 0: 1777: 100.00		KLK15_HUMAN (70-292): 1.92e-96: 286: 42.31
+	Hs
		287512 LRP6_HUMAN (1-1613): 0: 1777: 100.00		KLK3_HUMAN (58-292): 1.88e-94: 281: 40.89
+	Hs
		274933 LRP5_HUMAN (15-1613): 0: 1630: 70.08		KLK5_HUMAN (1-293): 3.05e-129: 370: 100.00
+	Hs
		274916 LRP5_HUMAN (15-1613): 0: 1630: 70.08		KLK15_HUMAN (70-292): 1.92e-96: 286: 42.31
+	Hs
		274851 LRP5_HUMAN (15-1613): 0: 1630: 70.08		KLK3_HUMAN (58-292): 1.88e-94: 281: 40.89
+	Hs
		376566 LDLR_HUMAN (1319-1611): 3.73e-21: 102: 10.79		KLK5_HUMAN (1-293): 3.05e-129: 370: 100.00
+	Hs
		1022528 VLDLR_HUMAN (1314-1613): 1.98e-28: 126: 11.77		ST14_HUMAN (23-288): 4.81e-95: 300: 32.04
+	Hs
		437661 VLDLR_HUMAN (1314-1613): 1.98e-28: 126: 11.77		HEPS_HUMAN (35-293): 5.05e-94: 285: 30.99
+	Hs
		376568 LDLR_HUMAN (1319-1611): 3.73e-21: 102: 10.79		ST14_HUMAN (23-288): 4.81e-95: 300: 32.04
+	Hs
		376547 LDLR_HUMAN (1319-1611): 3.73e-21: 102: 10.79		KLK15_HUMAN (70-292): 1.92e-96: 286: 42.31
+	Hs
		398002 NID2_HUMAN (542-627): 4.87e-10: 67: 21.59		KLKB1_HUMAN (57-292): 1.66e-92: 288: 33.07