HitPredict

Interactor 1: U520 (O75643)
U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD)
Gene: SNRNP200

Interactor 2: U520 (O75643)
U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD)
Gene: SNRNP200

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.898

The method score is based on:

Property Details
Experiments 25849387, 31839598, 16723661, 22365833
Identification Methods two hybrid, cross-linking study, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains BRR2_plug~Helicase_C, BRR2_plug~Helicase_PWI, BRR2_plug~Sec63, DEAD~DEAD, DEAD~Helicase_C, DEAD~Sec63, Helicase_C~Helicase_C, Helicase_C~Sec63, Helicase_PWI~Sec63, Sec63~Sec63
Common GO terms GO:0000354 - cis assembly of pre-catalytic spliceosome
GO:0000388 - spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
GO:0000398 - mRNA splicing, via spliceosome
GO:0001649 - osteoblast differentiation
GO:0003723 - RNA binding
and 15 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

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Hs

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Service provided by Combinatics, Japan

Last updated: 11Aug2025