HitPredict

Interactor 1: MPDZ (O75970)
Multiple PDZ domain protein (Multi-PDZ domain protein 1)
Gene: MPDZ

Interactor 2: LIN7B (Q9HAP6)
Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2)
Gene: LIN7B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	33961781, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	L27~L27_2, PDZ~PDZ
Common GO terms	GO:0005886 - plasma membrane GO:0005923 - bicellular tight junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2070 Hs			1 207
+	Hs
		299801 MPDZ_HUMAN (1-2070): 0: 1268: 100.00		LIN7C_HUMAN (1-196): 2.27e-58: 183: 84.69
+	Hs
		167672 MPDZ_HUMAN (1-2070): 0: 1268: 100.00		LIN7A_HUMAN (4-194): 5.1e-53: 171: 79.06
+	Hs
		1091570 DLG1_HUMAN (3-231): 4.29e-21: 103: 16.52		LIN7B_HUMAN (1-207): 4.02e-63: 196: 100.00
+	Hs
		1091580 DLG1_HUMAN (3-231): 4.29e-21: 103: 16.52		LIN7C_HUMAN (1-196): 2.27e-58: 183: 84.69
+	Hs
		167694 DLG1_HUMAN (3-231): 4.29e-21: 103: 16.52		LIN7A_HUMAN (4-194): 5.1e-53: 171: 79.06
+	Hs
		167712 INADL_HUMAN (3-263): 2.94e-20: 100: 16.03		LIN7A_HUMAN (4-194): 5.1e-53: 171: 79.06
+	Hs
		1104900 GRIP1_HUMAN (1685-2069): 4.3e-31: 136: 21.39		SNTB2_HUMAN (2-207): 5.63e-36: 133: 28.10
+	Mm
		1223740 MAGI3_MOUSE (2-709): 7.46e-28: 125: 12.45		DLG4_MOUSE (86-204): 1.67e-24: 102: 27.42
+	Hs
		168680 DLG1_HUMAN (3-231): 4.29e-21: 103: 16.52		CSKP_HUMAN (10-206): 2.29e-30: 119: 20.49
+	Rn
		723902 NHRF3_RAT (548-852): 3.4e-25: 114: 16.67		DLG4_RAT (86-204): 4.31e-24: 101: 27.42
+	Hs
		1091484 DLG1_HUMAN (3-231): 4.29e-21: 103: 16.52		DLG1_HUMAN (57-181): 2.16e-25: 104: 29.23
+	Hs
		1091503 DLG1_HUMAN (3-231): 4.29e-21: 103: 16.52		DLG2_HUMAN (89-202): 3.42e-25: 104: 29.41
+	Mm
		1190725 Q3UP61_MOUSE (3-231): 4.38e-21: 103: 18.70		DLG4_MOUSE (86-204): 1.67e-24: 102: 27.42
+	Rn
		1224262 DLG2_RAT (1031-1354): 1.29e-20: 101: 17.77		DLG1_RAT (57-191): 1.52e-24: 102: 25.71
+	Rn
		723875 GRIP1_RAT (5-504): 2.67e-20: 100: 14.52		DLG4_RAT (86-204): 4.31e-24: 101: 27.42
+	Dm
		723789 SCRIB_DROME (7-459): 1.68e-25: 118: 16.74		DLG1_DROME (7-198): 8.3e-18: 82.9: 20.79
+	Hs
		1401101 MAGI1_HUMAN (1438-2069): 1.07e-25: 118: 16.79		MAGI1_HUMAN (43-188): 1.68e-16: 79.1: 18.24
+	Hs
		1091548 DLG1_HUMAN (3-231): 4.29e-21: 103: 16.52		DLG3_HUMAN (29-164): 2.22e-20: 90.3: 25.53
+	Hs
		1288689 MAGI1_HUMAN (1438-2069): 1.07e-25: 118: 16.79		MAGI2_HUMAN (41-201): 5.41e-14: 71.8: 13.25
+	Hs
		1341088 MAGI1_HUMAN (1438-2069): 1.07e-25: 118: 16.79		INADL_HUMAN (5-198): 5.44e-12: 66: 19.43