HitPredict

Interactor 1: GLSK (O94925)
Glutaminase kidney isoform, mitochondrial (GLS) (EC 3.5.1.2) (K-glutaminase) (L-glutamine amidohydrolase) [Cleaved into: Glutaminase kidney isoform, mitochondrial 68 kDa chain; Glutaminase kidney isoform, mitochondrial 65 kDa chain]
Gene: GLS

Interactor 2: SHC2 (P98077)
SHC-transforming protein 2 (Protein Sck) (SHC-transforming protein B) (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2)
Gene: SHC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 669 Hs			1 582
+	Hs
		924929 GLSL_HUMAN (118-669): 0: 580: 71.33		GRB2_HUMAN (475-582): 5.69e-16: 79.1: 28.07
+	Hs
		1198938 LPP60_HUMAN (546-657): 1.8e-11: 69.3: 29.66		SHC3_HUMAN (82-581): 1.27e-122: 375: 49.71
+	Mm
		970499 ANK1_MOUSE (430-669): 1.9e-34: 143: 12.31		ANS1B_MOUSE (26-366): 5.11e-50: 188: 14.01
+	Hs
		655524 MYO16_HUMAN (342-669): 1.58e-52: 198: 15.84		P85A_HUMAN (427-578): 3.1e-23: 106: 19.23
+	Hs
		411697 ANK3_HUMAN (488-666): 4.57e-33: 139: 15.64		LCK_HUMAN (321-582): 1.49e-36: 144: 14.60
+	Hs
		433392 ANR12_HUMAN (537-643): 7.48e-30: 128: 22.43		YES_HUMAN (330-573): 5.09e-39: 152: 16.41
+	Hs
		208966 PSD10_HUMAN (481-660): 5.42e-32: 125: 14.44		NCK2_HUMAN (271-578): 3.22e-39: 149: 13.29
+	Hs
		433389 ANR54_HUMAN (535-644): 2.92e-27: 114: 25.89		YES_HUMAN (330-573): 5.09e-39: 152: 16.41
+	Hs
		523028 ANR54_HUMAN (535-644): 2.92e-27: 114: 25.89		SRC_HUMAN (326-573): 4.48e-39: 152: 15.06
+	Hs
		557660 ANK2_HUMAN (540-669): 2.52e-25: 114: 21.54		NCK1_HUMAN (456-574): 4.57e-35: 137: 24.59
+	Mm
		103593 ANK3_MOUSE (280-605): 3.25e-30: 129: 11.97		P85A_MOUSE (427-578): 3.1e-23: 106: 19.23
+	Hs
		411885 KDIS_HUMAN (455-623): 6.51e-16: 84.3: 13.45		LCK_HUMAN (321-582): 1.49e-36: 144: 14.60
+	Hs
		1192758 ANR50_HUMAN (261-558): 1.74e-12: 73.2: 10.64		CLNK_HUMAN (201-579): 1.42e-40: 154: 13.33
+	Mm
		643090 MYO16_MOUSE (560-662): 5.06e-17: 87.8: 18.45		P85A_MOUSE (427-578): 3.1e-23: 106: 19.23
+	Hs
		924484 ANK2_HUMAN (540-669): 2.52e-25: 114: 21.54		GRB2_HUMAN (475-582): 5.69e-16: 79.1: 28.07
+	Hs
		655290 RIPK4_HUMAN (543-669): 1.7e-15: 82.4: 15.75		P85A_HUMAN (427-578): 3.1e-23: 106: 19.23
+	Hs
		655466 Q9H4D1_HUMAN (543-669): 1.6e-15: 82.4: 15.75		P85A_HUMAN (427-578): 3.1e-23: 106: 19.23
+	Hs
		1267436 Q9H4D1_HUMAN (543-669): 1.6e-15: 82.4: 15.75		P55G_HUMAN (482-580): 2.6e-16: 83.8: 33.01
+	Hs
		883587 RIPK4_HUMAN (543-669): 1.7e-15: 82.4: 15.75		P55G_HUMAN (482-580): 2.6e-16: 83.8: 33.01
+	Hs
		225151 MYPT2_HUMAN (528-667): 4.68e-15: 81.2: 21.83		P55G_HUMAN (482-580): 2.6e-16: 83.8: 33.01