HitPredict

Interactor 1: A0A0S2Z4D7 (A0A0S2Z4D7)
NCK adaptor protein 1 isoform 2 (NCK adaptor protein 1, isoform CRA_b)
Gene: NCK1

Interactor 2: TNFL6 (P48023)
Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand) (APTL) (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]
Gene: FASLG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.50	0.417

Property	Details
Experiments	26871637
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 170 Hs			1 281
+	Hs
		442792 HCK_HUMAN (2-169): 1.03e-52: 176: 21.59		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		433642 LYN_HUMAN (2-169): 2.46e-51: 172: 18.75		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		411638 LCK_HUMAN (3-169): 3.75e-50: 169: 19.43		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		454807 FGR_HUMAN (6-166): 2.81e-47: 162: 19.41		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		412082 FYN_HUMAN (6-160): 4.63e-46: 159: 20.73		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		433285 YES_HUMAN (6-166): 4.01e-44: 154: 20.00		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		522855 SRC_HUMAN (6-166): 2.04e-43: 152: 18.82		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		815674 ITK_HUMAN (3-168): 9.28e-37: 135: 21.71		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		815673 BTK_HUMAN (2-168): 1.74e-36: 134: 20.57		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		815671 GRB2_HUMAN (3-60): 1.43e-18: 80.9: 29.31		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		557638 NCK1_HUMAN (7-76): 1.37e-14: 72: 25.71		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		815700 ES8L3_HUMAN (10-66): 3.81e-13: 68.2: 31.58		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		788978 TEC_HUMAN (4-61): 4.21e-13: 67.8: 33.90		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		209004 NCK2_HUMAN (9-124): 8.01e-13: 67: 25.21		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		352447 LYN_HUMAN (2-169): 2.46e-51: 172: 18.75		TNFA_HUMAN (70-281): 3.29e-73: 225: 26.46
+	Hs
		352441 FYN_HUMAN (6-160): 4.63e-46: 159: 20.73		TNFA_HUMAN (70-281): 3.29e-73: 225: 26.46
+	Hs
		155678 SRC_HUMAN (6-166): 2.04e-43: 152: 18.82		TNF11_HUMAN (138-281): 1.95e-54: 180: 23.57