Protein: KCNN4
Intermediate conductance calcium-activated potassium channel protein 4 (SKCa 4) (SKCa4) (hSK4) (Gardos channel) (IKCa1) (hIK1) (KCa3.1) (Putative Gardos channel) (hKCa4)

Gene: KCNN4
Organism: Homo sapiens
Interactions: 69
UniProt ID: O15554

Gene Ontology (top 5):
GO:0002376 - immune system process
GO:0005267 - potassium channel activity
GO:0005516 - calmodulin binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

194819

TNNC1
Troponin C, slow skeletal and cardiac muscles

1

6

High-throughput

0.691

High

194841

RYR2
Ryanodine receptor 2

1

3

Small-scale

0.647

High

194856

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

2

High-throughput

0.618

High

194811

MUC18
Cell surface glycoprotein MUC18

1

4

High-throughput

0.618

High

194818

STX1B
Syntaxin-1B

2

4

High-throughput

0.606

High

194838

GP152
Probable G-protein coupled receptor 152

2

4

High-throughput

0.606

High

194849

ZNT2
Proton-coupled zinc antiporter SLC30A2

2

3

High-throughput

0.606

High

194796

CREB3
Cyclic AMP-responsive element-binding protein 3

2

2

High-throughput

0.601

High

194817

CXCR4
C-X-C chemokine receptor type 4

2

2

High-throughput

0.601

High

194842

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

2

4

High-throughput

0.601

High

194820

PMP22
Peripheral myelin protein 22

2

0

High-throughput

0.580

High

194826

FXYD3
FXYD domain-containing ion transport regulator 3

2

0

High-throughput

0.580

High

125086

LEG9
Galectin-9

1

2

High-throughput

0.536

High

141798

ACKR2
Atypical chemokine receptor 2

1

3

High-throughput

0.536

High

165864

FFAR1
Free fatty acid receptor 1

1

3

High-throughput

0.536

High

169223

CASQ2
Calsequestrin-2

1

3

High-throughput

0.536

High

182416

GP182
G-protein coupled receptor 182

1

3

High-throughput

0.536

High

194800

LEG1
Galectin-1

1

2

High-throughput

0.536

High

194805

PGAM2
Phosphoglycerate mutase 2

1

1

High-throughput

0.536

High

194806

LEG3
Galectin-3

1

2

High-throughput

0.536

High

194822

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

1

High-throughput

0.536

High

194823

TRDN
Triadin

1

6

High-throughput

0.536

High

194824

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

4

High-throughput

0.536

High

194831

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.536

High

194833

CR3L3
Cyclic AMP-responsive element-binding protein 3-like protein 3

1

2

High-throughput

0.536

High

194834

S39A4
Zinc transporter ZIP4

1

2

High-throughput

0.536

High

194839

KCNE4
Potassium voltage-gated channel subfamily E member 4

1

3

High-throughput

0.536

High

194803

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

Small-scale

0.529

High

194797

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

High-throughput

0.513

High

194804

GPIX
Platelet glycoprotein IX

1

0

High-throughput

0.513

High

194807

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.513

High

194808

SDC2
Syndecan-2

1

0

High-throughput

0.513

High

194810

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.513

High

194812

DHYS
Deoxyhypusine synthase

1

0

High-throughput

0.513

High

194827

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.513

High

194828

AMHR2
Anti-Muellerian hormone type-2 receptor

1

0

High-throughput

0.513

High

194832

TRML2
Trem-like transcript 2 protein

1

0

High-throughput

0.513

High

194836

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

194844

TSN17
Tetraspanin-17

1

0

High-throughput

0.513

High

194846

OPALI
Opalin

1

0

High-throughput

0.513

High

194855

BL1S6
Biogenesis of lysosome-related organelles complex 1 subunit 6

1

0

High-throughput

0.513

High

194858

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

194821

CAC1D
Voltage-dependent L-type calcium channel subunit alpha-1D

1

1

Small-scale

0.501

High

194840

JPH3
Junctophilin-3

1

2

Small-scale

0.501

High

194845

JPH4
Junctophilin-4

1

2

Small-scale

0.501

High

194801

DC8L2
DDB1- and CUL4-associated factor 8-like protein 2

1

2

High-throughput

0.489

High

194802

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

194809

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

2

Small-scale

0.479

High

194813

RAB7A
Ras-related protein Rab-7a

1

3

Small-scale

0.479

High

194816

RAB8A
Ras-related protein Rab-8A

1

2

Small-scale

0.479

High

194848

TS101
Tumor susceptibility gene 101 protein

1

0

Small-scale

0.458

High

194851

PHP14
14 kDa phosphohistidine phosphatase

1

0

Small-scale

0.458

High

194814

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

1

Small-scale

0.457

High

194798

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

1

High-throughput

0.445

High

194799

ISG15
Ubiquitin-like protein ISG15

1

6

Small-scale

0.445

High

194847

FEZ1
Fasciculation and elongation protein zeta-1

1

0

High-throughput

0.426

High

194852

MS18A
Protein Mis18-alpha

1

0

High-throughput

0.426

High

194815

EVA1C
Protein eva-1 homolog C

1

1

High-throughput

0.407

High

194825

BIK
Bcl-2-interacting killer

2

0

High-throughput

0.316

High

194837

CNIH3
Protein cornichon homolog 3

2

0

High-throughput

0.316

High

194795

B4GA1
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.279

Low

194829

P3H1
Prolyl 3-hydroxylase 1

1

0

High-throughput

0.279

Low

194830

SHSL1
Protein shisa-like-1

1

0

High-throughput

0.279

Low

194853

USE1
Vesicle transport protein USE1

1

0

High-throughput

0.279

Low

194854

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.279

Low

194857

NGN3
Neurogenin-3

1

0

High-throughput

0.279

Low

194835

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.232

Low

194843

SAAL1
Protein SAAL1

1

0

High-throughput

0.232

Low

194850

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025