Protein: BTK
Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase)

Gene: BTK
Organism: Homo sapiens
Interactions: 117
UniProt ID: Q06187

Gene Ontology (top 5):
GO:0001780 - neutrophil homeostasis
GO:0001805 - positive regulation of type III hypersensitivity
GO:0001812 - positive regulation of type I hypersensitivity
GO:0002250 - adaptive immune response
GO:0002344 - B cell affinity maturation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

986366

BTK
Tyrosine-protein kinase BTK

8

20

Small-scale

0.968

High

986387

BLNK
B-cell linker protein

6

20

Small-scale

0.937

High

986383

ANR54
Ankyrin repeat domain-containing protein 54

4

15

High-throughput

0.903

High

986402

IBTK
Inhibitor of Bruton tyrosine kinase

3

8

Small-scale

0.870

High

924503

GRB2
Growth factor receptor-bound protein 2

2

20

High-throughput

0.817

High

986407

M3K4
Mitogen-activated protein kinase kinase kinase 4

2

4

High-throughput

0.811

High

442813

HCK
Tyrosine-protein kinase HCK

2

19

Small-scale

0.799

High

986392

KTNB1
Katanin p80 WD40 repeat-containing subunit B1

2

7

High-throughput

0.789

High

986400

TLR9
Toll-like receptor 9

2

20

Small-scale

0.775

High

986401

TLR8
Toll-like receptor 8

2

19

Small-scale

0.775

High

986388

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

20

High-throughput

0.767

High

786602

STA5A
Signal transducer and activator of transcription 5A

1

15

Small-scale

0.761

High

562642

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

2

16

Small-scale

0.754

High

942144

GTF2I
General transcription factor II-I

6

1

Small-scale

0.743

High

337440

ABL1
Tyrosine-protein kinase ABL1

1

18

Small-scale

0.724

High

986377

KPCD1
Serine/threonine-protein kinase D1

1

13

Small-scale

0.724

High

341500

UROK
Urokinase-type plasminogen activator

1

2

High-throughput

0.698

High

790664

WASP
Actin nucleation-promoting factor WAS

4

20

Small-scale

0.696

High

441489

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

986372

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.692

High

360640

SPTA1
Spectrin alpha chain, erythrocytic 1

1

18

Small-scale

0.691

High

521527

ACTN1
Alpha-actinin-1

1

6

Small-scale

0.691

High

598078

FLNA
Filamin-A

1

10

Small-scale

0.691

High

665469

EPHA8
Ephrin type-A receptor 8

1

20

High-throughput

0.691

High

986368

TWF1
Twinfilin-1

1

2

Small-scale

0.691

High

986379

DREB
Drebrin

1

7

Small-scale

0.691

High

986395

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

11

Small-scale

0.691

High

610368

CBL
E3 ubiquitin-protein ligase CBL

4

20

Small-scale

0.671

High

431769

HS90A
Heat shock protein HSP 90-alpha

3

20

High-throughput

0.667

High

848352

IRAK1
Interleukin-1 receptor-associated kinase 1

1

20

Small-scale

0.665

High

981049

KPCT
Protein kinase C theta type

1

20

Small-scale

0.665

High

120149

TLR4
Toll-like receptor 4

1

19

Small-scale

0.656

High

986405

TLR6
Toll-like receptor 6

1

20

Small-scale

0.656

High

160528

AURKA
Aurora kinase A

1

13

Small-scale

0.647

High

408609

KPCB
Protein kinase C beta type

1

20

Small-scale

0.647

High

412147

FYN
Tyrosine-protein kinase Fyn

1

19

Small-scale

0.647

High

433717

LYN
Tyrosine-protein kinase Lyn

1

19

Small-scale

0.647

High

601902

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

616702

KS6B1
Ribosomal protein S6 kinase beta-1

1

20

Small-scale

0.647

High

986397

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

12

Small-scale

0.647

High

986403

KS6B2
Ribosomal protein S6 kinase beta-2

1

20

Small-scale

0.647

High

225238

3BP5
SH3 domain-binding protein 5

2

0

Small-scale

0.629

High

986378

CDC37
Hsp90 co-chaperone Cdc37

2

12

High-throughput

0.628

High

438098

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.621

High

348630

RASN
GTPase NRas

1

20

High-throughput

0.618

High

349264

RASH
GTPase HRas

1

20

High-throughput

0.618

High

350101

RASK
GTPase KRas

1

20

High-throughput

0.618

High

386587

P53
Cellular tumor antigen p53

1

6

High-throughput

0.618

High

548690

VAV
Proto-oncogene vav

1

20

Small-scale

0.618

High

616803

JAK1
Tyrosine-protein kinase JAK1

1

19

Small-scale

0.618

High

683983

1433S
14-3-3 protein sigma

1

20

High-throughput

0.618

High

776660

STAT3
Signal transducer and activator of transcription 3

1

15

Small-scale

0.618

High

796550

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

920945

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

6

Small-scale

0.618

High

986376

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.618

High

885996

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

2

0

Small-scale

0.598

High

986391

ARI3A
AT-rich interactive domain-containing protein 3A

2

1

Small-scale

0.594

High

986374

BECN1
Beclin-1

2

2

High-throughput

0.576

High

986385

TTC9C
Tetratricopeptide repeat protein 9C

2

13

High-throughput

0.574

High

837944

MEOX2
Homeobox protein MOX-2

1

8

High-throughput

0.573

High

986367

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

2

19

Small-scale

0.563

High

837606

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

1

Small-scale

0.561

High

962745

MDM2
E3 ubiquitin-protein ligase Mdm2

1

5

Small-scale

0.561

High

986404

COR1C
Coronin-1C

1

5

Small-scale

0.553

High

827176

ARRB1
Beta-arrestin-1

1

8

High-throughput

0.541

High

487364

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

986371

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

20

Small-scale

0.536

High

133994

DDX3X
ATP-dependent RNA helicase DDX3X

1

3

Small-scale

0.536

High

238957

LPXN
Leupaxin

1

20

High-throughput

0.536

High

381945

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

3

Small-scale

0.536

High

415304

ATPB
ATP synthase subunit beta, mitochondrial

1

4

Small-scale

0.536

High

531557

K2C5
Keratin, type II cytoskeletal 5

1

2

Small-scale

0.536

High

613428

SFPQ
Splicing factor, proline- and glutamine-rich

1

7

Small-scale

0.536

High

636899

ATPA
ATP synthase subunit alpha, mitochondrial

1

4

Small-scale

0.536

High

932964

ACTS
Actin, alpha skeletal muscle

1

5

Small-scale

0.536

High

933412

TBA4A
Tubulin alpha-4A chain

1

10

Small-scale

0.536

High

933767

TBB4B
Tubulin beta-4B chain

1

6

Small-scale

0.536

High

984335

EF1A2
Elongation factor 1-alpha 2

1

2

Small-scale

0.536

High

986384

HORN
Hornerin

1

1

Small-scale

0.536

High

986406

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

5

Small-scale

0.536

High

946856

RT22
Small ribosomal subunit protein mS22

2

1

High-throughput

0.526

High

596880

MAL
Myelin and lymphocyte protein

1

4

Small-scale

0.515

High

986390

MYD88
Myeloid differentiation primary response protein MyD88

1

15

Small-scale

0.515

High

986396

MED28
Mediator of RNA polymerase II transcription subunit 28

1

8

Small-scale

0.515

High

72910

B4DMH3
Coronin

1

4

Small-scale

0.514

High

616270

RS3
Small ribosomal subunit protein uS3

1

0

Small-scale

0.513

High

658047

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

0

Small-scale

0.513

High

394587

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

815673

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

12

Small-scale

0.501

High

986369

COASY
Bifunctional coenzyme A synthase

1

2

Small-scale

0.501

High

986382

RHG17
Rho GTPase-activating protein 17

1

20

Small-scale

0.501

High

986394

TMG4
Transmembrane gamma-carboxyglutamic acid protein 4

1

6

Small-scale

0.501

High

778123

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

1

Small-scale

0.489

High

206737

B2L11
Bcl-2-like protein 11

1

0

Small-scale

0.480

High

209913

PRC1
Protein regulator of cytokinesis 1

1

8

High-throughput

0.479

High

632254

TNR6
Tumor necrosis factor receptor superfamily member 6

1

12

Small-scale

0.479

High

672953

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

1

3

Small-scale

0.479

High

781346

BCL6
B-cell lymphoma 6 protein

1

2

Small-scale

0.479

High

880294

TCL1A
T-cell leukemia/lymphoma protein 1A

1

1

High-throughput

0.479

High

967124

EWS
RNA-binding protein EWS

1

3

Small-scale

0.479

High

974777

CAV1
Caveolin-1

1

10

Small-scale

0.479

High

986370

CBLB
E3 ubiquitin-protein ligase CBL-B

1

20

Small-scale

0.479

High

986389

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

986398

GPVI
Platelet glycoprotein VI

1

16

Small-scale

0.479

High

986399

PDE7B
3',5'-cyclic-AMP phosphodiesterase 7B

1

6

High-throughput

0.479

High

986386

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

239955

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

8

High-throughput

0.445

High

353927

IGHM
Immunoglobulin heavy constant mu

1

10

Small-scale

0.445

High

382398

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

2

High-throughput

0.445

High

548200

CD19
B-lymphocyte antigen CD19

1

2

Small-scale

0.445

High

986373

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

4

High-throughput

0.445

High

986375

RFTN1
Raftlin

1

1

Small-scale

0.445

High

986380

H90B3
Putative heat shock protein HSP 90-beta-3

1

20

High-throughput

0.445

High

986381

HS905
Putative heat shock protein HSP 90-alpha A5

1

20

High-throughput

0.445

High

986393

ACTBM
Putative beta-actin-like protein 3

1

6

Small-scale

0.445

High

823920

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

11

High-throughput

0.437

High


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024