HitPredict

Interactor 1: CBX6 (O95503)
Chromobox protein homolog 6
Gene: CBX6

Interactor 2: H15 (P16401)
Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3)
Gene: H1-5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 21282530
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0000792 - heterochromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0006325 - chromatin organization
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 412 Hs			1 226
+	Hs
		315962 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		H12_HUMAN (32-174): 1.09e-17: 80.2: 75.17
+	Hs
		315955 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		H14_HUMAN (1-118): 3.82e-17: 78.6: 87.29
+	Hs
		316015 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		H11_HUMAN (1-186): 2.89e-15: 73.6: 61.29
+	Hs
		559255 CBX8_HUMAN (1-393): 2.31e-76: 243: 30.82		H15_HUMAN (1-118): 3.29e-18: 81.7: 100.00
+	Hs
		489290 CBX8_HUMAN (1-393): 2.31e-76: 243: 30.82		H14_HUMAN (1-118): 3.82e-17: 78.6: 87.29
+	Hs
		123239 CBX4_HUMAN (1-362): 3.71e-34: 135: 23.28		H11_HUMAN (1-186): 2.89e-15: 73.6: 61.29
+	Dm
		355220 HP1_DROME (11-118): 1.69e-25: 104: 27.52		H1_DROME (2-225): 1.13e-26: 104: 32.89
+	Mm
		794626 CBX5_MOUSE (11-106): 1.59e-27: 109: 29.17		H14_MOUSE (1-206): 2.81e-20: 87.1: 63.77
+	Hs
		559009 CBX5_HUMAN (11-106): 3.1e-28: 111: 29.17		H15_HUMAN (1-118): 3.29e-18: 81.7: 100.00
+	Mm
		794637 Q9DCC5_MOUSE (9-121): 1.26e-25: 104: 24.56		H14_MOUSE (1-206): 2.81e-20: 87.1: 63.77
+	Hs
		488936 CBX5_HUMAN (11-106): 3.1e-28: 111: 29.17		H14_HUMAN (1-118): 3.82e-17: 78.6: 87.29
+	Mm
		794619 CBX1_MOUSE (17-85): 6.16e-23: 97.1: 34.78		H14_MOUSE (1-206): 2.81e-20: 87.1: 63.77
+	Hs
		489023 CBX3_HUMAN (9-121): 1.26e-25: 104: 24.56		H14_HUMAN (1-118): 3.82e-17: 78.6: 87.29
+	Mm
		794648 CBX5_MOUSE (11-106): 1.59e-27: 109: 29.17		H11_MOUSE (1-124): 1e-14: 72.1: 67.74