HitPredict

Interactor 1: KLH18 (O94889)
Kelch-like protein 18
Gene: KLHL18

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.975

Property	Details
Experiments	23213400, 28514442, 33292627, 33961781, 37495603, 33130828, 34878901, 35563538, 21145461, 19295130, 34591642
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BACK~Cullin, BTB~Cullin
Common GO terms	GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination GO:0031463 - Cul3-RING ubiquitin ligase complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:1901992 - positive regulation of mitotic cell cycle phase transition
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 574 Hs			1 768
+	Hs
		1114702 KLH20_HUMAN (8-570): 1.2e-174: 509: 42.02		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Hs
		1113453 KLH17_HUMAN (7-572): 6.73e-163: 480: 42.76		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Rn
		81587 KLH17_RAT (7-572): 1.58e-163: 481: 42.76		CUL3_RAT (1-768): 0: 942: 99.61
+	Hs
		1113274 KLH26_HUMAN (14-572): 3.49e-161: 475: 28.70		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Mm
		1440934 KEAP1_MOUSE (4-568): 8.63e-160: 471: 33.62		CUL3_MOUSE (1-768): 0: 941: 99.48
+	Hs
		1114518 KLHL8_HUMAN (3-572): 9.26e-157: 464: 34.90		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Hs
		1114239 KLHL4_HUMAN (3-571): 3.98e-154: 460: 36.87		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Dm
		1232817 Q6GKZ1_DROME (21-566): 0: 541: 27.40		Q8IP45_DROME (17-768): 0: 857: 69.08
+	Hs
		1113399 KLH10_HUMAN (1-573): 1.07e-152: 453: 30.38		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Dm
		1232820 Q6GKZ1_DROME (21-566): 0: 541: 27.40		Q9V475_DROME (2-768): 0: 850: 68.77
+	Mm
		1424094 KLH10_MOUSE (1-573): 1.47e-151: 450: 30.21		CUL3_MOUSE (1-768): 0: 941: 99.48
+	Dm
		1304395 KLHDB_DROME (7-570): 1.61e-171: 502: 41.59		Q8IP45_DROME (17-768): 0: 857: 69.08
+	Hs
		1113634 KLHL7_HUMAN (26-551): 4.44e-96: 306: 33.58		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Hs
		1113862 KLHL6_HUMAN (28-547): 4.53e-82: 270: 31.10		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Rn
		73324 KLH17_RAT (7-572): 1.58e-163: 481: 42.76		B1WBY1_RAT (17-768): 0: 710: 30.53
+	Hs
		1112703 KLHL4_HUMAN (3-571): 3.98e-154: 460: 36.87		CUL1_HUMAN (18-768): 0: 709: 30.57
+	Hs
		1114054 KLHL5_HUMAN (365-572): 1.85e-59: 212: 38.46		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Hs
		1114400 KLHL1_HUMAN (369-571): 1.82e-57: 207: 36.45		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Hs
		320836 KLH18_HUMAN (1-574): 5.12e-175: 508: 100.00		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Dm
		1304386 Q9VGE5_DROME (383-573): 2.97e-52: 189: 38.02		Q8IP45_DROME (17-768): 0: 857: 69.08