HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: KLHL4 (Q9C0H6)
Kelch-like protein 4
Gene: KLHL4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	37495603, 32753315, 21145461, 30190310
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BACK~Cullin, BTB~Cullin
Common GO terms	GO:0005737 - cytoplasm GO:0031463 - Cul3-RING ubiquitin ligase complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 718
+	Hs
		1114400 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL1_HUMAN (1-718): 0: 562: 63.28
+	Hs
		1113077 CUL3_HUMAN (1-768): 0: 943: 100.00		KEAP1_HUMAN (100-718): 1.57e-161: 481: 31.48
+	Hs
		1114525 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH13_HUMAN (95-715): 3.53e-160: 479: 27.40
+	Hs
		1113453 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH17_HUMAN (148-717): 3.12e-158: 474: 40.49
+	Hs
		1114520 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL9_HUMAN (135-715): 3.85e-157: 470: 28.11
+	Hs
		320822 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH18_HUMAN (151-717): 8.72e-158: 470: 36.60
+	Hs
		329059 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL2_HUMAN (130-718): 8.37e-154: 460: 36.29
+	Hs
		1114459 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH28_HUMAN (164-715): 2.35e-150: 451: 37.90
+	Hs
		1113274 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH26_HUMAN (159-718): 7.11e-138: 420: 27.75
+	Hs
		1113271 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH22_HUMAN (130-718): 1.22e-135: 415: 24.75
+	Hs
		1113634 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL7_HUMAN (172-715): 5.87e-81: 270: 30.92
+	Hs
		1113267 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH12_HUMAN (112-618): 1.41e-49: 184: 19.22
+	Hs
		1114054 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL5_HUMAN (598-718): 1.2e-22: 105: 33.06
+	Hs
		1113862 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL6_HUMAN (368-570): 1.55e-22: 104: 20.98
+	Hs
		161296 CUL3_HUMAN (1-768): 0: 943: 100.00		ENC1_HUMAN (558-717): 1.85e-20: 98: 22.49
+	Hs
		1114259 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH25_HUMAN (554-717): 9.7e-20: 95.8: 21.97
+	Hs
		1113454 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH24_HUMAN (355-570): 3.22e-19: 94.2: 20.64
+	Hs
		1114518 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL8_HUMAN (617-718): 2.22e-16: 85: 27.45
+	Hs
		1113399 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH10_HUMAN (311-523): 1.06e-15: 83: 21.76
+	Hs
		1113682 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH36_HUMAN (616-716): 3.19e-10: 65.3: 25.47