HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: RAP2C (Q9Y3L5)
Ras-related protein Rap-2c (EC 3.6.5.2)
Gene: RAP2C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	32640226, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1239 Hs			1 183
+	Hs
		324724 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RAP2A_HUMAN (1-183): 7.54e-103: 295: 91.26
+	Hs
		324774 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RB11A_HUMAN (4-177): 1.26e-72: 219: 29.71
+	Hs
		486037 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RAP2A_HUMAN (1-183): 7.54e-103: 295: 91.26
+	Hs
		486057 TNIK_HUMAN (1-1239): 0: 1101: 60.56		RAP2A_HUMAN (1-183): 7.54e-103: 295: 91.26
+	Xl
		1150218 Q6DDZ8_XENLA (1-1239): 0: 1097: 59.58		Q7ZX67_XENLA (1-183): 3.34e-82: 242: 90.16
+	Hs
		148636 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		RAB1A_HUMAN (4-170): 1.34e-76: 229: 35.71
+	Hs
		149274 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		RAB1B_HUMAN (4-179): 2.04e-76: 228: 33.33
+	Hs
		647864 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RB11A_HUMAN (4-177): 1.26e-72: 219: 29.71
+	Hs
		148551 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		RAB13_HUMAN (4-179): 1.04e-72: 219: 32.20
+	Hs
		914159 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		RB11A_HUMAN (4-177): 1.26e-72: 219: 29.71
+	Dm
		442965 HIPPO_DROME (14-316): 8.94e-108: 356: 40.79		RAP1_DROME (1-165): 6.26e-80: 237: 64.24
+	Hs
		254466 ROCK2_HUMAN (15-536): 8.84e-107: 369: 22.02		RB11A_HUMAN (4-177): 1.26e-72: 219: 29.71
+	Hs
		914488 M4K5_HUMAN (4-375): 4.65e-107: 359: 39.52		RB11A_HUMAN (4-177): 1.26e-72: 219: 29.71
+	Hs
		914500 STK24_HUMAN (20-398): 2.05e-110: 355: 36.65		RB11A_HUMAN (4-177): 1.26e-72: 219: 29.71