HitPredict

Interactor 1: UBR5 (O95071)
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Gene: UBR5

Interactor 2: UB2D4 (Q9Y2X8)
Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)
Gene: UBE2D4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	37409633
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0005634 - nucleus GO:0035519 - protein K29-linked ubiquitination GO:0070936 - protein K48-linked ubiquitination GO:0070979 - protein K11-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2799 Hs			1 147
+	Hs
		325740 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2D1_HUMAN (1-147): 3.33e-83: 242: 91.84
+	Hs
		325776 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2D2_HUMAN (1-147): 7.67e-83: 241: 93.20
+	Hs
		325765 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2D3_HUMAN (1-147): 8.57e-82: 238: 91.84
+	Hs
		325987 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2E2_HUMAN (4-146): 2.83e-75: 224: 64.34
+	Hs
		325968 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2E3_HUMAN (4-146): 1.06e-74: 223: 64.34
+	Hs
		325741 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2E1_HUMAN (4-146): 3.9e-73: 218: 64.34
+	Hs
		325726 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UBE2A_HUMAN (2-144): 5.16e-71: 211: 41.26
+	Hs
		325780 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UBE2B_HUMAN (2-144): 2.29e-70: 210: 39.86
+	Hs
		906687 HECW1_HUMAN (2170-2798): 2.45e-168: 568: 20.31		UB2D1_HUMAN (1-147): 3.33e-83: 242: 91.84
+	Hs
		982221 HECW1_HUMAN (2170-2798): 2.45e-168: 568: 20.31		UB2D2_HUMAN (1-147): 7.67e-83: 241: 93.20
+	Hs
		957112 HECW1_HUMAN (2170-2798): 2.45e-168: 568: 20.31		UB2D3_HUMAN (1-147): 8.57e-82: 238: 91.84
+	Hs
		982349 HECW2_HUMAN (2170-2798): 1.03e-139: 482: 19.72		UB2D2_HUMAN (1-147): 7.67e-83: 241: 93.20
+	Hs
		957222 HECW2_HUMAN (2170-2798): 1.03e-139: 482: 19.72		UB2D3_HUMAN (1-147): 8.57e-82: 238: 91.84
+	Hs
		906789 SMUF1_HUMAN (2357-2796): 2.48e-141: 463: 21.18		UB2D1_HUMAN (1-147): 3.33e-83: 242: 91.84
+	Hs
		982329 SMUF1_HUMAN (2357-2796): 2.48e-141: 463: 21.18		UB2D2_HUMAN (1-147): 7.67e-83: 241: 93.20
+	Hs
		957206 SMUF1_HUMAN (2357-2796): 2.48e-141: 463: 21.18		UB2D3_HUMAN (1-147): 8.57e-82: 238: 91.84
+	Hs
		906788 SMUF2_HUMAN (2405-2796): 3.91e-134: 442: 22.36		UB2D1_HUMAN (1-147): 3.33e-83: 242: 91.84
+	Hs
		982327 SMUF2_HUMAN (2405-2796): 3.91e-134: 442: 22.36		UB2D2_HUMAN (1-147): 7.67e-83: 241: 93.20
+	Hs
		906748 ITCH_HUMAN (2187-2797): 8.98e-132: 440: 18.08		UB2D1_HUMAN (1-147): 3.33e-83: 242: 91.84
+	Hs
		957205 SMUF2_HUMAN (2405-2796): 3.91e-134: 442: 22.36		UB2D3_HUMAN (1-147): 8.57e-82: 238: 91.84