HitPredict

Interactor 1: EPN2 (O95208)
Epsin-2 (EPS-15-interacting protein 2)
Gene: EPN2

Interactor 2: FGFR4 (P22455)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Gene: FGFR4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005768 - endosome GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 641 Hs			1 802
+	Hs
		329420 EPN2_HUMAN (1-641): 2.42e-114: 358: 100.00		FGFR1_HUMAN (3-794): 0: 714: 54.76
+	Hs
		648512 EPN4_HUMAN (3-638): 1.87e-95: 308: 22.15		FGFR4_HUMAN (13-802): 0: 755: 100.00
+	Hs
		641174 EPN4_HUMAN (3-638): 1.87e-95: 308: 22.15		FGFR2_HUMAN (4-797): 0: 748: 56.44
+	Hs
		541489 EPN4_HUMAN (3-638): 1.87e-95: 308: 22.15		FGFR1_HUMAN (3-794): 0: 714: 54.76
+	Hs
		329427 EPN2_HUMAN (1-641): 2.42e-114: 358: 100.00		EPHA2_HUMAN (4-789): 0: 587: 19.52
+	Hs
		541789 EPN1_HUMAN (1-570): 4.8e-64: 223: 39.27		FGFR1_HUMAN (3-794): 0: 714: 54.76
+	Hs
		931852 EPN4_HUMAN (3-638): 1.87e-95: 308: 22.15		EPHA5_HUMAN (4-771): 0: 615: 18.43
+	Hs
		1129808 EPN4_HUMAN (3-638): 1.87e-95: 308: 22.15		EPHA7_HUMAN (4-781): 0: 605: 19.78
+	Hs
		650461 DAPLE_HUMAN (97-634): 7.8e-29: 125: 12.58		FGFR3_HUMAN (5-799): 0: 720: 61.07
+	Hs
		1129810 EPN4_HUMAN (3-638): 1.87e-95: 308: 22.15		NTRK3_HUMAN (159-751): 2.57e-165: 501: 25.24
+	Hs
		411933 EPN4_HUMAN (3-638): 1.87e-95: 308: 22.15		NTRK1_HUMAN (135-751): 2.17e-160: 487: 26.53
+	Hs
		463964 EPN4_HUMAN (3-638): 1.87e-95: 308: 22.15		RET_HUMAN (221-802): 2.72e-146: 459: 34.72
+	Hs
		412907 EPN1_HUMAN (1-570): 4.8e-64: 223: 39.27		NTRK1_HUMAN (135-751): 2.17e-160: 487: 26.53
+	Hs
		464092 EPN1_HUMAN (1-570): 4.8e-64: 223: 39.27		RET_HUMAN (221-802): 2.72e-146: 459: 34.72
+	Hs
		640196 OTOG_HUMAN (162-638): 1.95e-22: 105: 11.04		EPHA1_HUMAN (3-789): 2.38e-177: 536: 19.55
+	Mm
		777820 EPN2_MOUSE (1-641): 2.2e-104: 330: 71.61		VGFR3_MOUSE (41-369): 3.65e-17: 88.6: 17.74
+	Bt
		98940 F1N579_BOVIN (1-580): 7.46e-69: 236: 39.29		F1MWF1_BOVIN (28-376): 4.35e-24: 110: 16.03
+	Hs
		778121 EPN1_HUMAN (1-570): 4.8e-64: 223: 39.27		VGFR2_HUMAN (74-376): 3.49e-24: 111: 16.67
+	Mm
		777819 EPN1_MOUSE (1-570): 1.31e-60: 214: 38.82		VGFR3_MOUSE (41-369): 3.65e-17: 88.6: 17.74
+	Hs
		777811 EPN1_HUMAN (1-570): 4.8e-64: 223: 39.27		VGFR3_HUMAN (153-356): 9.27e-11: 67.8: 18.78