HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: BLNK (Q8WV28)
B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65)
Gene: BLNK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016020 - membrane GO:0019899 - enzyme binding GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 456
+	Hs
		129152 EGFR_HUMAN (1-1210): 0: 1241: 100.00		P85B_HUMAN (129-453): 1.23e-44: 168: 17.05
+	Hs
		337978 EGFR_HUMAN (1-1210): 0: 1241: 100.00		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Rn
		94037 Q9QX70_RAT (1-1210): 0: 1241: 90.34		F1LN91_RAT (10-436): 3.74e-39: 153: 16.36
+	Hs
		338635 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CLNK_HUMAN (73-443): 8.86e-38: 144: 21.35
+	Hs
		338356 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LCP2_HUMAN (14-442): 1.33e-33: 134: 25.27
+	Hs
		338776 EGFR_HUMAN (1-1210): 0: 1241: 100.00		P55G_HUMAN (327-453): 3.31e-27: 115: 24.41
+	Hs
		338552 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TENS3_HUMAN (10-436): 9.07e-25: 109: 15.25
+	Hs
		338550 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TENS2_HUMAN (45-436): 3.69e-23: 105: 18.06
+	Hs
		339003 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TENS1_HUMAN (18-436): 4.14e-23: 105: 14.61
+	Hs
		338683 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TENS4_HUMAN (81-436): 3.69e-20: 95.6: 13.70
+	Hs
		338769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TITIN_HUMAN (33-310): 7.65e-11: 67: 13.83
+	Hs
		129295 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		P85B_HUMAN (129-453): 1.23e-44: 168: 17.05
+	Hs
		655377 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Mm
		643074 ERBB2_MOUSE (5-1200): 0: 1116: 48.46		P85A_MOUSE (121-453): 4.26e-43: 163: 14.41
+	Hs
		1024132 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		LCP2_HUMAN (14-442): 1.33e-33: 134: 25.27
+	Hs
		1070991 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		P55G_HUMAN (327-453): 3.31e-27: 115: 24.41
+	Hs
		1070975 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		TENS3_HUMAN (10-436): 9.07e-25: 109: 15.25
+	Hs
		1070974 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		TENS2_HUMAN (45-436): 3.69e-23: 105: 18.06
+	Hs
		1071015 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		TENS1_HUMAN (18-436): 4.14e-23: 105: 14.61
+	Hs
		1070981 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		TENS4_HUMAN (81-436): 3.69e-20: 95.6: 13.70