HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: OSMR (Q99650)
Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta) (IL-31 receptor subunit beta) (IL-31R subunit beta) (IL-31R-beta) (IL-31RB)
Gene: OSMR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27110918
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Furin-like~fn3, PK_Tyr_Ser-Thr~fn3, Recep_L_domain~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation GO:0016324 - apical plasma membrane GO:0043235 - receptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 979
+	Mm
		250890 EGFR_MOUSE (1-1210): 0: 1258: 90.35		OSMR_MOUSE (1-977): 1.39e-180: 551: 55.01
+	Hs
		383948 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		OSMR_HUMAN (1-979): 0: 597: 100.00
+	Hs
		338085 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LIFR_HUMAN (27-968): 1.24e-107: 361: 26.46
+	Hs
		338057 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IL6RB_HUMAN (147-827): 2.76e-106: 354: 21.57
+	Hs
		383660 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		IL6RB_HUMAN (147-827): 2.76e-106: 354: 21.57
+	Hs
		601828 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		IL6RB_HUMAN (147-827): 2.76e-106: 354: 21.57
+	Hs
		337831 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRF_HUMAN (3-533): 1.16e-36: 152: 10.04
+	Hs
		338012 EGFR_HUMAN (1-1210): 0: 1241: 100.00		L1CAM_HUMAN (142-959): 1.76e-31: 135: 9.50
+	Rn
		984693 Q8K3F9_RAT (5-1200): 0: 1129: 48.85		L1CAM_RAT (42-973): 4.67e-62: 232: 9.72
+	Hs
		337941 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRD_HUMAN (424-977): 2.07e-25: 116: 8.71
+	Hs
		338769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TITIN_HUMAN (333-618): 1.08e-09: 65.2: 7.17
+	Rn
		984692 ERBB3_RAT (1-1180): 0: 1070: 41.32		L1CAM_RAT (42-973): 4.67e-62: 232: 9.72
+	Hs
		383644 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		L1CAM_HUMAN (142-959): 1.76e-31: 135: 9.50
+	Hs
		601825 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		L1CAM_HUMAN (142-959): 1.76e-31: 135: 9.50
+	Hs
		434120 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		PTPRF_HUMAN (3-533): 1.16e-36: 152: 10.04
+	Rn
		544873 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		CNTN1_RAT (147-962): 9.13e-39: 158: 8.35
+	Hs
		265771 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		CRLF1_HUMAN (144-433): 1.31e-25: 112: 19.75
+	Mm
		514127 FAK1_MOUSE (716-991): 5.99e-54: 207: 37.68		L1CAM_MOUSE (42-973): 1.12e-63: 237: 9.55
+	Hs
		983646 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		NEO1_HUMAN (3-526): 6.94e-31: 133: 12.26
+	Hs
		793638 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		DCC_HUMAN (2-429): 4.6e-21: 101: 8.72