HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: CD166 (Q13740)
CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166)
Gene: ALCAM

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.51	0.60	0.554

Property	Details
Experiments	16799092
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 583
+	Hs
		363714 EGFR_HUMAN (1-1210): 0: 1246: 100.00		KIRR1_HUMAN (5-582): 5.78e-76: 258: 14.93
+	Hs
		362932 EGFR_HUMAN (1-1210): 0: 1246: 100.00		MUC18_HUMAN (1-575): 4.49e-75: 253: 20.26
+	Hs
		410828 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		CD166_HUMAN (1-583): 4.7e-116: 358: 100.00
+	Hs
		362680 EGFR_HUMAN (1-1210): 0: 1246: 100.00		NCAM1_HUMAN (26-527): 1.86e-41: 162: 13.48
+	Hs
		411001 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		KIRR1_HUMAN (5-582): 5.78e-76: 258: 14.93
+	Hs
		410697 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		MUC18_HUMAN (1-575): 4.49e-75: 253: 20.26
+	Hs
		641516 ERBB3_HUMAN (1-1205): 0: 1102: 41.39		MUC18_HUMAN (1-575): 4.49e-75: 253: 20.26
+	Hs
		363819 EGFR_HUMAN (1-1210): 0: 1246: 100.00		CADM1_HUMAN (259-493): 5.64e-20: 94.9: 19.64
+	Hs
		410811 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		PTK7_HUMAN (18-577): 3.16e-54: 200: 11.86
+	Hs
		363306 EGFR_HUMAN (1-1210): 0: 1246: 100.00		RAGE_HUMAN (253-548): 1.79e-12: 71.4: 15.78
+	Hs
		363641 EGFR_HUMAN (1-1210): 0: 1246: 100.00		TITIN_HUMAN (294-555): 1.07e-09: 63.9: 12.85
+	Hs
		411034 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		CADM1_HUMAN (259-493): 5.64e-20: 94.9: 19.64
+	Hs
		898375 EPHA7_HUMAN (653-1064): 3.04e-119: 396: 27.51		BCAM_HUMAN (26-505): 1.09e-81: 270: 23.62
+	Hs
		1147408 EPHA7_HUMAN (653-1064): 3.04e-119: 396: 27.51		KIRR1_HUMAN (5-582): 5.78e-76: 258: 14.93
+	Hs
		710428 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		KIRR1_HUMAN (5-582): 5.78e-76: 258: 14.93
+	Hs
		463952 RET_HUMAN (412-1058): 7.91e-132: 433: 23.02		PTK7_HUMAN (18-577): 3.16e-54: 200: 11.86
+	Hs
		710112 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		MUC18_HUMAN (1-575): 4.49e-75: 253: 20.26
+	Hs
		710220 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		PTK7_HUMAN (18-577): 3.16e-54: 200: 11.86
+	Hs
		710375 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		CADM4_HUMAN (252-575): 6.21e-20: 94.2: 19.67
+	Hs
		710503 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		ROBO2_HUMAN (15-467): 9.05e-17: 86.3: 11.32