HitPredict

Interactor 1: PLF4 (P02776)
Platelet factor 4 (PF-4) (C-X-C motif chemokine 4) (Iroplact) (Oncostatin-A) [Cleaved into: Platelet factor 4, short form (Endothelial cell growth inhibitor)]
Gene: PF4

Interactor 2: SDF1 (P48061)
Stromal cell-derived factor 1 (SDF-1) (hSDF-1) (C-X-C motif chemokine 12) (Intercrine reduced in hepatomas) (IRH) (hIRH) (Pre-B cell growth-stimulating factor) (PBSF) [Cleaved into: SDF-1-beta(3-72); SDF-1-alpha(3-67)]
Gene: CXCL12

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.812

Property	Details
Experiments	28381538, 10233851
Identification Methods	pull down, surface plasmon resonance, filter binding
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	IL8~IL8
Common GO terms	GO:0005576 - extracellular region GO:0008009 - chemokine activity GO:0045236 - CXCR chemokine receptor binding GO:0062023 - collagen-containing extracellular matrix GO:0070098 - chemokine-mediated signaling pathway
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 101 Hs			1 93
+	Hs
		364045 CXCL7_HUMAN (26-99): 4.02e-28: 100: 50.00		SDF1_HUMAN (1-93): 4.72e-52: 159: 100.00
+	Hs
		587773 CXCL2_HUMAN (30-101): 1.79e-28: 100: 41.67		SDF1_HUMAN (1-93): 4.72e-52: 159: 100.00
+	Hs
		816312 CXCL6_HUMAN (28-101): 7.85e-27: 96.6: 40.54		SDF1_HUMAN (1-93): 4.72e-52: 159: 100.00
+	Hs
		499206 PF4V_HUMAN (9-101): 8.75e-25: 91.2: 89.25		SDF1_HUMAN (1-93): 4.72e-52: 159: 100.00
+	Hs
		364104 CXL10_HUMAN (17-98): 1.58e-21: 82.8: 26.19		SDF1_HUMAN (1-93): 4.72e-52: 159: 100.00
+	Hs
		816314 CXCL9_HUMAN (31-97): 3.46e-21: 82.8: 27.94		SDF1_HUMAN (1-93): 4.72e-52: 159: 100.00
+	Hs
		150316 CXL11_HUMAN (17-98): 4.33e-21: 81.6: 22.62		SDF1_HUMAN (1-93): 4.72e-52: 159: 100.00