HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: SRSF5 (Q13243)
Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)
Gene: SRSF5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21182205
Identification Methods	affinity chromatography technology, cosedimentation through density gradient
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 272
+	Hs
		369476 ESR1_HUMAN (1-595): 0: 599: 100.00		SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68
+	Hs
		369529 ESR1_HUMAN (1-595): 0: 599: 100.00		SRSF6_HUMAN (5-184): 1.35e-48: 165: 61.96
+	Hs
		370350 ESR1_HUMAN (1-595): 0: 599: 100.00		RBM4_HUMAN (3-122): 5.32e-17: 81.7: 22.50
+	Hs
		369534 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP4_HUMAN (104-189): 3.45e-16: 80.1: 21.98
+	Hs
		369739 ESR1_HUMAN (1-595): 0: 599: 100.00		PAP1L_HUMAN (105-189): 5.16e-16: 79.4: 16.67
+	Hs
		368886 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP1_HUMAN (98-189): 1.16e-15: 78.6: 18.56
+	Hs
		370422 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP3_HUMAN (98-189): 8.72e-15: 75.9: 18.56
+	Hs
		369064 ESR1_HUMAN (1-595): 0: 599: 100.00		TIA1_HUMAN (2-101): 1.95e-12: 68.6: 16.67
+	Hs
		369421 ESR1_HUMAN (1-595): 0: 599: 100.00		TIAR_HUMAN (3-103): 3.49e-12: 67.4: 14.56
+	Hs
		369401 ESR1_HUMAN (1-595): 0: 599: 100.00		SRSF3_HUMAN (4-78): 1.85e-11: 62.8: 47.56
+	Hs
		1028757 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SRSF5_HUMAN (1-240): 2.63e-54: 178: 100.00
+	Hs
		993786 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64
+	Hs
		1028586 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SRSF9_HUMAN (2-211): 1.47e-52: 172: 33.02
+	Hs
		377273 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68
+	Hs
		1031409 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PABP4_HUMAN (104-189): 3.45e-16: 80.1: 21.98
+	Hs
		1119140 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PAP1L_HUMAN (105-189): 5.16e-16: 79.4: 16.67
+	Hs
		1269600 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PABP3_HUMAN (98-189): 8.72e-15: 75.9: 18.56
+	Hs
		680471 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TIA1_HUMAN (2-101): 1.95e-12: 68.6: 16.67
+	Hs
		963552 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TIAR_HUMAN (3-103): 3.49e-12: 67.4: 14.56
+	Hs
		782537 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		PABP4_HUMAN (104-189): 3.45e-16: 80.1: 21.98