HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	27483141, 9222609
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 457
+	Hs
		369442 ESR1_HUMAN (1-595): 0: 599: 100.00		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		369479 ESR1_HUMAN (1-595): 0: 599: 100.00		PPID_HUMAN (249-414): 4.11e-51: 178: 24.55
+	Hs
		370658 ESR1_HUMAN (1-595): 0: 599: 100.00		FKBPL_HUMAN (133-414): 4.04e-51: 178: 25.70
+	Hs
		377301 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		1025252 NR1H3_HUMAN (99-548): 6.2e-112: 343: 20.49		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		437640 MCR_HUMAN (21-554): 3.98e-103: 335: 22.01		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Mm
		415159 GCR_MOUSE (5-557): 4.61e-107: 341: 21.82		FKBP5_MOUSE (1-457): 1.26e-140: 412: 86.87
+	Hs
		377261 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Mm
		415156 GCR_MOUSE (5-557): 4.61e-107: 341: 21.82		FKBP4_MOUSE (1-444): 7.18e-136: 400: 55.38
+	Hs
		437634 MCR_HUMAN (21-554): 3.98e-103: 335: 22.01		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		369598 ESR1_HUMAN (1-595): 0: 599: 100.00		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		369072 ESR1_HUMAN (1-595): 0: 599: 100.00		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		414489 PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		377276 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		PPID_HUMAN (249-414): 4.11e-51: 178: 24.55
+	Hs
		1053109 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		1025273 NR1H3_HUMAN (99-548): 6.2e-112: 343: 20.49		FKBPL_HUMAN (133-414): 4.04e-51: 178: 25.70
+	Hs
		437638 MCR_HUMAN (21-554): 3.98e-103: 335: 22.01		PPID_HUMAN (249-414): 4.11e-51: 178: 24.55
+	Hs
		118677 MCR_HUMAN (21-554): 3.98e-103: 335: 22.01		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		377132 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		414449 PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62