HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: CNKR1 (Q969H4)
Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR 1) (CNK homolog protein 1) (CNK1) (hCNK1) (Connector enhancer of KSR-like)
Gene: CNKSR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	15075335
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~PH, PH~Pkinase
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 648 Hs			1 720
+	Hs
		374065 RAF1_HUMAN (1-648): 0: 652: 100.00		SPTB2_HUMAN (12-538): 1.01e-75: 268: 13.64
+	Hs
		374608 RAF1_HUMAN (1-648): 0: 652: 100.00		CNKR2_HUMAN (77-719): 2.72e-59: 218: 18.20
+	Hs
		164550 RAF1_HUMAN (1-648): 0: 652: 100.00		SPTN2_HUMAN (12-552): 1.63e-50: 193: 13.76
+	Hs
		374867 RAF1_HUMAN (1-648): 0: 652: 100.00		PKHA4_HUMAN (383-502): 7.85e-26: 115: 26.40
+	Hs
		488804 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		PKHA4_HUMAN (383-502): 7.85e-26: 115: 26.40
+	Dm
		507724 KRAF1_DROME (45-647): 6.35e-165: 491: 44.98		Q7KNQ9_DROME (243-601): 6.95e-22: 103: 16.45
+	Hs
		1217987 KSR1_HUMAN (138-648): 6.15e-108: 348: 24.61		PKHA5_HUMAN (330-717): 1.02e-47: 184: 15.74
+	Hs
		1153279 KSR1_HUMAN (138-648): 6.15e-108: 348: 24.61		PKHA7_HUMAN (323-700): 1.06e-40: 162: 15.29
+	Hs
		433388 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		PKHA7_HUMAN (323-700): 1.06e-40: 162: 15.29
+	Hs
		269517 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		SKAP2_HUMAN (362-584): 1.05e-39: 152: 16.38
+	Hs
		269512 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		SKAP2_HUMAN (362-584): 1.05e-39: 152: 16.38
+	Hs
		269511 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		SKAP2_HUMAN (362-584): 1.05e-39: 152: 16.38
+	Hs
		1203487 KSR1_HUMAN (138-648): 6.15e-108: 348: 24.61		SKAP1_HUMAN (398-546): 1.13e-21: 99.2: 22.22
+	Hs
		412353 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		PKHA4_HUMAN (383-502): 7.85e-26: 115: 26.40
+	Hs
		523046 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		SKAP1_HUMAN (398-546): 1.13e-21: 99.2: 22.22
+	Hs
		412249 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		SKAP1_HUMAN (398-546): 1.13e-21: 99.2: 22.22
+	Gg
		337667 SRC_CHICK (331-607): 2.94e-106: 333: 33.45		AFAP1_CHICK (234-719): 2.46e-14: 78.6: 12.38
+	Mm
		763391 FYN_MOUSE (342-607): 7.04e-40: 155: 35.29		SKAP2_MOUSE (362-584): 4.37e-42: 158: 18.75
+	Dm
		1096609 Q24170_DROME (250-631): 9.11e-49: 185: 36.80		Q7KNQ9_DROME (243-601): 6.95e-22: 103: 16.45
+	Dm
		1096611 Q24171_DROME (250-631): 9.45e-49: 185: 36.80		Q7KNQ9_DROME (243-601): 6.95e-22: 103: 16.45