HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: Q4LE69 (Q4LE69)
Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67)
Gene: PIK4CA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.80	0.739

Property	Details
Experiments	30442766, 30639242, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~Ras
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 2121
+	Hs
		374648 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		373967 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		1144933 RAB35_HUMAN (4-187): 1.26e-82: 244: 31.28		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		374446 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		PK3CA_HUMAN (1461-2117): 1.73e-151: 500: 21.77
+	Mm
		839128 RASH_MOUSE (1-188): 8.44e-87: 254: 86.77		PK3CA_MOUSE (1461-2117): 3.47e-151: 499: 21.92
+	Hs
		132783 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		PK3CD_HUMAN (1451-2118): 3.91e-151: 498: 18.48
+	Hs
		373816 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		PK3CA_HUMAN (1461-2117): 1.73e-151: 500: 21.77
+	Mm
		470808 RASN_MOUSE (1-189): 4.56e-86: 252: 85.71		PK3CA_MOUSE (1461-2117): 3.47e-151: 499: 21.92
+	Mm
		205662 RASH_MOUSE (1-188): 8.44e-87: 254: 86.77		PK3CD_MOUSE (1451-2118): 1.26e-147: 488: 19.05
+	Mm
		205655 RASN_MOUSE (1-189): 4.56e-86: 252: 85.71		PK3CD_MOUSE (1451-2118): 1.26e-147: 488: 19.05
+	Hs
		375260 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		PK3CA_HUMAN (1461-2117): 1.73e-151: 500: 21.77
+	Mm
		746557 RASK_MOUSE (16-189): 2.81e-78: 233: 98.85		PK3CA_MOUSE (1461-2117): 3.47e-151: 499: 21.92
+	Mm
		1222729 RASH_MOUSE (1-188): 8.44e-87: 254: 86.77		PK3CB_MOUSE (1465-2118): 2.74e-140: 468: 18.62
+	Mm
		205660 RASK_MOUSE (16-189): 2.81e-78: 233: 98.85		PK3CD_MOUSE (1451-2118): 1.26e-147: 488: 19.05
+	Hs
		374461 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		PK3CG_HUMAN (1522-2119): 7.19e-133: 448: 19.56
+	Hs
		373831 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		PK3CG_HUMAN (1522-2119): 7.19e-133: 448: 19.56
+	Mm
		1222737 RASH_MOUSE (1-188): 8.44e-87: 254: 86.77		PK3CG_MOUSE (1522-2119): 4.67e-131: 443: 19.87
+	Mm
		470810 RASN_MOUSE (1-189): 4.56e-86: 252: 85.71		PK3CG_MOUSE (1522-2119): 4.67e-131: 443: 19.87
+	Dm
		473597 RAS1_DROME (1-165): 9.67e-88: 257: 85.46		P91634_DROME (1439-2118): 1.16e-127: 433: 16.17
+	Mm
		746567 RASK_MOUSE (16-189): 2.81e-78: 233: 98.85		PK3CG_MOUSE (1522-2119): 4.67e-131: 443: 19.87