HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: PLEK2 (Q9NYT0)
Pleckstrin-2
Gene: PLEK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30639242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 353
+	Hs
		374703 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		FGD6_HUMAN (6-353): 5.47e-43: 161: 18.77
+	Hs
		375645 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		FGD6_HUMAN (6-353): 5.47e-43: 161: 18.77
+	Hs
		373798 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		AKT1_HUMAN (248-353): 2.51e-27: 113: 23.85
+	Hs
		374572 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		GAB1_HUMAN (246-349): 2.51e-25: 109: 25.89
+	Hs
		374939 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		PKHA5_HUMAN (2-132): 2.08e-25: 109: 19.55
+	Hs
		728589 RAB35_HUMAN (4-187): 1.26e-82: 244: 31.28		AKT2_HUMAN (248-353): 1.01e-28: 117: 25.69
+	Hs
		373913 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		GAB1_HUMAN (246-349): 2.51e-25: 109: 25.89
+	Hs
		374202 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		PKHA5_HUMAN (2-132): 2.08e-25: 109: 19.55
+	Hs
		1106475 RAB35_HUMAN (4-187): 1.26e-82: 244: 31.28		GAB1_HUMAN (246-349): 2.51e-25: 109: 25.89
+	Hs
		1145117 RAB35_HUMAN (4-187): 1.26e-82: 244: 31.28		PKHA5_HUMAN (2-132): 2.08e-25: 109: 19.55
+	Hs
		375224 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		AKT2_HUMAN (248-353): 1.01e-28: 117: 25.69
+	Hs
		374203 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		PKHA1_HUMAN (206-352): 8.21e-20: 91.6: 22.45
+	Hs
		375489 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		GAB1_HUMAN (246-349): 2.51e-25: 109: 25.89
+	Hs
		375964 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		PKHA5_HUMAN (2-132): 2.08e-25: 109: 19.55
+	Hs
		1145118 RAB35_HUMAN (4-187): 1.26e-82: 244: 31.28		PKHA1_HUMAN (206-352): 8.21e-20: 91.6: 22.45
+	Hs
		375965 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		PKHA2_HUMAN (3-217): 2.55e-22: 98.9: 17.94
+	Hs
		375966 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		PKHA1_HUMAN (206-352): 8.21e-20: 91.6: 22.45
+	Hs
		1140280 RAB35_HUMAN (4-187): 1.26e-82: 244: 31.28		ACAP2_HUMAN (196-351): 8.97e-14: 74.3: 19.75
+	Hs
		375583 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		DOC11_HUMAN (166-352): 2.55e-13: 73.5: 12.63
+	Hs
		375408 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		FGD1_HUMAN (2-141): 6.05e-10: 62.7: 16.67