Protein: DOC11
Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2)

Gene: DOC11, DOCK11
Organism: Homo sapiens
Interactions: 51
UniProt ID: Q5JSL3

Gene Ontology (top 5):
GO:0001782 - B cell homeostasis
GO:0002315 - marginal zone B cell differentiation
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0007264 - small GTPase-mediated signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1206375

DOCK9
Dedicator of cytokinesis protein 9

3

12

High-throughput

0.817

High

1206366

RHG22
Rho GTPase-activating protein 22

2

6

High-throughput

0.811

High

729900

1433B
14-3-3 protein beta/alpha

5

20

High-throughput

0.722

High

966412

1433G
14-3-3 protein gamma

4

20

High-throughput

0.699

High

1049367

1433F
14-3-3 protein eta

4

20

High-throughput

0.699

High

691075

1433T
14-3-3 protein theta

4

20

High-throughput

0.697

High

990306

1433Z
14-3-3 protein zeta/delta

4

20

High-throughput

0.697

High

318800

RHBT1
Rho-related BTB domain-containing protein 1

1

20

High-throughput

0.618

High

375583

RASK
GTPase KRas

1

14

High-throughput

0.618

High

581092

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

601317

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

920015

PLK1
Serine/threonine-protein kinase PLK1

1

9

High-throughput

0.618

High

953486

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

955260

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

978059

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

988420

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1206379

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

716486

GFRP
GTP cyclohydrolase 1 feedback regulatory protein

2

0

High-throughput

0.602

High

1206378

PAAT
ATPase PAAT

2

1

High-throughput

0.574

High

1206376

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.553

High

1206377

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.553

High

971603

1433E
14-3-3 protein epsilon

1

5

High-throughput

0.536

High

1068225

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

High-throughput

0.493

High

345911

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

535151

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.479

High

730639

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

789511

PPARG
Peroxisome proliferator-activated receptor gamma

1

3

High-throughput

0.479

High

830866

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

902929

DUS3
Dual specificity protein phosphatase 3

1

2

High-throughput

0.479

High

1092730

RHG05
Rho GTPase-activating protein 5

1

5

High-throughput

0.479

High

1206363

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

1206370

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

1206371

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1206380

RCC2
Protein RCC2

1

2

Small-scale

0.479

High

1029311

SET
Protein SET

1

0

High-throughput

0.458

High

1095264

REST
RE1-silencing transcription factor

1

0

High-throughput

0.458

High

843637

HD
Huntingtin

1

2

High-throughput

0.457

High

114438

H0Y572
Dedicator of cytokinesis 9

1

3

High-throughput

0.445

High

1206373

CYGB
Cytoglobin

1

1

Small-scale

0.445

High

1206364

MOB3C
MOB kinase activator 3C

1

11

High-throughput

0.437

High

1206365

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1206367

MOB3B
MOB kinase activator 3B

1

11

High-throughput

0.437

High

1206368

KTN1
Kinectin

1

4

High-throughput

0.437

High

1206369

SIR6
NAD-dependent protein deacylase sirtuin-6

1

2

High-throughput

0.437

High

1206372

CE192
Centrosomal protein of 192 kDa

1

0

High-throughput

0.426

High

220695

DENR
Density-regulated protein

2

0

High-throughput

0.328

High

462781

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

2

0

High-throughput

0.328

High

1206374

GORS1
Golgi reassembly-stacking protein 1

2

0

High-throughput

0.328

High

339509

ACSL3
Fatty acid CoA ligase Acsl3

1

0

High-throughput

0.269

Low

390065

ALBU
Albumin

1

0

High-throughput

0.249

Low

814536

FEN1
Flap endonuclease 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025