HitPredict

Interactor 1: H2B2 (P02294)
Histone H2B.2
Gene: HTB2

Interactor 2: HOS3 (Q02959)
Histone deacetylase HOS3 (EC 3.5.1.98)
Gene: HOS3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	37968396, 21179020
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Hist_deacetyl~Histone
Common GO terms	GO:0005634 - nucleus GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 131 Sc			1 697
+	Hs
		1368085 H2B1M_HUMAN (7-129): 1.24e-47: 151: 68.80		HDAC2_HUMAN (48-600): 1.32e-139: 419: 10.81
+	Hs
		1163105 H2B2E_HUMAN (7-129): 4.64e-47: 149: 70.40		HDAC2_HUMAN (48-600): 1.32e-139: 419: 10.81
+	Hs
		754926 H2B1B_HUMAN (7-129): 1.3e-46: 148: 69.60		HDAC2_HUMAN (48-600): 1.32e-139: 419: 10.81
+	Hs
		1323945 H2B3B_HUMAN (7-129): 1.74e-45: 145: 64.00		HDAC2_HUMAN (48-600): 1.32e-139: 419: 10.81
+	Hs
		1368086 H2B1L_HUMAN (7-129): 3.58e-45: 144: 69.60		HDAC2_HUMAN (48-600): 1.32e-139: 419: 10.81
+	Hs
		1109772 H2B2E_HUMAN (7-129): 4.64e-47: 149: 70.40		HDAC1_HUMAN (47-552): 3.13e-136: 410: 11.94
+	Hs
		754833 H2B1B_HUMAN (7-129): 1.3e-46: 148: 69.60		HDAC1_HUMAN (47-552): 3.13e-136: 410: 11.94
+	Hs
		980745 H2B1C_HUMAN (7-129): 9.05e-47: 148: 70.40		HDAC1_HUMAN (47-552): 3.13e-136: 410: 11.94
+	Hs
		1109889 H2B3B_HUMAN (7-129): 1.74e-45: 145: 64.00		HDAC1_HUMAN (47-552): 3.13e-136: 410: 11.94
+	Hs
		257017 H2B1K_HUMAN (7-129): 1.29e-46: 148: 69.60		HDAC5_HUMAN (3-468): 8.65e-118: 381: 16.67
+	Sc
		381020 H2B1_YEAST (1-131): 4.06e-44: 142: 96.95		RPD3_YEAST (39-532): 1.49e-125: 381: 11.85
+	At
		1424675 H2B10_ARATH (3-128): 8.21e-46: 147: 58.33		HDA6_ARATH (48-576): 1.37e-115: 357: 11.40
+	Hs
		1408039 H2B1M_HUMAN (7-129): 1.24e-47: 151: 68.80		HDAC6_HUMAN (68-433): 3.96e-75: 265: 19.78
+	Hs
		257009 H2B1K_HUMAN (7-129): 1.29e-46: 148: 69.60		HDAC6_HUMAN (68-433): 3.96e-75: 265: 19.78
+	Hs
		755016 H2B1B_HUMAN (7-129): 1.3e-46: 148: 69.60		HDAC6_HUMAN (68-433): 3.96e-75: 265: 19.78
+	Hs
		946899 H2B1D_HUMAN (7-129): 2.51e-46: 148: 69.60		HDAC6_HUMAN (68-433): 3.96e-75: 265: 19.78
+	Hs
		1408062 H2B1L_HUMAN (7-129): 3.58e-45: 144: 69.60		HDAC6_HUMAN (68-433): 3.96e-75: 265: 19.78
+	Sc
		381589 H2B2_YEAST (1-131): 1.09e-45: 146: 100.00		HDA1_YEAST (49-438): 3.77e-60: 216: 19.70
+	Sc
		381204 H2B1_YEAST (1-131): 4.06e-44: 142: 96.95		HDA1_YEAST (49-438): 3.77e-60: 216: 19.70
+	Sc
		381570 H2B2_YEAST (1-131): 1.09e-45: 146: 100.00		HOS2_YEAST (47-390): 1.82e-18: 90.7: 14.99