HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: PCGF2 (P35227)
Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144)
Gene: PCGF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	16248985
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 344
+	Hs
		385501 LMNA_HUMAN (1-664): 1.26e-79: 267: 100.00		BMI1_HUMAN (1-341): 8.74e-98: 294: 61.40
+	Hs
		634326 LMNB1_HUMAN (21-581): 1.2e-49: 184: 54.45		PCGF2_HUMAN (1-344): 2.57e-117: 344: 100.00
+	Hs
		765424 LMNB2_HUMAN (21-581): 2.95e-51: 189: 52.59		BMI1_HUMAN (1-341): 8.74e-98: 294: 61.40
+	Hs
		341739 K2C75_HUMAN (24-390): 1.17e-46: 175: 23.64		BMI1_HUMAN (1-341): 8.74e-98: 294: 61.40
+	Hs
		302356 K2C5_HUMAN (24-390): 2e-117: 365: 25.95		RNF8_HUMAN (2-101): 6.39e-23: 101: 25.00
+	Hs
		302300 K2C6A_HUMAN (23-407): 4.96e-116: 360: 23.71		RNF8_HUMAN (2-101): 6.39e-23: 101: 25.00
+	Hs
		302308 K2C6B_HUMAN (24-407): 4.84e-115: 357: 23.51		RNF8_HUMAN (2-101): 6.39e-23: 101: 25.00
+	Hs
		765580 K2C71_HUMAN (6-390): 2.41e-42: 162: 21.71		BMI1_HUMAN (1-341): 8.74e-98: 294: 61.40
+	Hs
		765615 K2C79_HUMAN (23-398): 5.49e-42: 161: 22.16		BMI1_HUMAN (1-341): 8.74e-98: 294: 61.40
+	Hs
		570365 GFAP_HUMAN (27-427): 1.13e-28: 121: 27.43		BMI1_HUMAN (1-341): 8.74e-98: 294: 61.40
+	Hs
		606079 DESM_HUMAN (27-389): 6.13e-28: 119: 30.03		BMI1_HUMAN (1-341): 8.74e-98: 294: 61.40
+	Hs
		385447 LMNA_HUMAN (1-664): 1.26e-79: 267: 100.00		RO52_HUMAN (8-210): 6.11e-32: 126: 15.02
+	Hs
		386260 LMNA_HUMAN (1-664): 1.26e-79: 267: 100.00		TRI39_HUMAN (9-186): 2.9e-27: 113: 16.58
+	Hs
		302301 LMNA_HUMAN (1-664): 1.26e-79: 267: 100.00		RNF8_HUMAN (2-101): 6.39e-23: 101: 25.00
+	Hs
		1042060 LMNB2_HUMAN (21-581): 2.95e-51: 189: 52.59		RING2_HUMAN (4-234): 5.89e-45: 158: 17.49
+	Hs
		623093 LMNB1_HUMAN (21-581): 1.2e-49: 184: 54.45		RO52_HUMAN (8-210): 6.11e-32: 126: 15.02
+	Hs
		474920 VIME_HUMAN (27-389): 3.96e-31: 129: 28.93		RING2_HUMAN (4-234): 5.89e-45: 158: 17.49
+	Hs
		474468 VIME_HUMAN (27-389): 3.96e-31: 129: 28.93		RO52_HUMAN (8-210): 6.11e-32: 126: 15.02
+	Hs
		474891 VIME_HUMAN (27-389): 3.96e-31: 129: 28.93		CHFR_HUMAN (8-150): 4.7e-28: 116: 17.93