HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: ATD3A (Q9NVI7)
ATPase family AAA domain-containing protein 3A (EC 3.6.1.-)
Gene: ATAD3A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.50	0.558

Property	Details
Experiments	33731348, 21182205
Identification Methods	affinity chromatography technology, cosedimentation through density gradient
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 586
+	Hs
		395760 ESR1_HUMAN (1-595): 0: 599: 100.00		TERA_HUMAN (3-582): 3.92e-137: 420: 15.31
+	Hs
		396278 ESR1_HUMAN (1-595): 0: 599: 100.00		ATD3C_HUMAN (199-586): 5.42e-122: 368: 84.06
+	Hs
		395833 ESR1_HUMAN (1-595): 0: 599: 100.00		PRS10_HUMAN (172-574): 1.01e-100: 312: 16.59
+	Hs
		397318 ESR1_HUMAN (1-595): 0: 599: 100.00		AFG32_HUMAN (220-575): 7.27e-70: 242: 19.14
+	Hs
		934939 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		TERA_HUMAN (3-582): 3.92e-137: 420: 15.31
+	Hs
		625789 RXRA_HUMAN (65-551): 4.57e-127: 383: 26.47		TERA_HUMAN (3-582): 3.92e-137: 420: 15.31
+	Hs
		1214738 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		ATD3B_HUMAN (41-586): 4.07e-118: 366: 93.41
+	Hs
		704512 RXRB_HUMAN (144-549): 1.91e-111: 345: 27.64		TERA_HUMAN (3-582): 3.92e-137: 420: 15.31
+	Hs
		396527 ESR1_HUMAN (1-595): 0: 599: 100.00		AFG2A_HUMAN (2-285): 3.7e-39: 155: 11.85
+	Mm
		542854 RARA_MOUSE (81-545): 8.39e-104: 323: 22.37		TERA_MOUSE (3-582): 3.92e-137: 420: 15.31
+	Hs
		520540 RARA_HUMAN (81-545): 1.36e-102: 320: 22.37		TERA_HUMAN (3-582): 3.92e-137: 420: 15.31
+	Hs
		789454 PPARG_HUMAN (55-546): 2.13e-100: 316: 20.35		TERA_HUMAN (3-582): 3.92e-137: 420: 15.31
+	Hs
		975476 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		PRS10_HUMAN (172-574): 1.01e-100: 312: 16.59
+	Hs
		404122 GCR_HUMAN (5-557): 4.69e-109: 346: 22.51		ATD3B_HUMAN (41-586): 4.07e-118: 366: 93.41
+	Hs
		343283 ERR2_HUMAN (92-547): 4.32e-116: 354: 34.86		ATD3A_HUMAN (41-586): 7.3e-114: 353: 100.00
+	Hs
		404472 GCR_HUMAN (5-557): 4.69e-109: 346: 22.51		ATD3A_HUMAN (41-586): 7.3e-114: 353: 100.00
+	Hs
		1367684 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		AFG32_HUMAN (220-575): 7.27e-70: 242: 19.14
+	Hs
		1333182 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		AFG2A_HUMAN (2-285): 3.7e-39: 155: 11.85
+	Hs
		188512 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		NVL_HUMAN (1-256): 1.25e-35: 144: 10.73
+	Hs
		188426 ANDR_HUMAN (172-455): 8.99e-37: 148: 30.16		NVL_HUMAN (1-256): 1.25e-35: 144: 10.73