HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	28205554
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008285 - negative regulation of cell population proliferation GO:0035019 - somatic stem cell population maintenance
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 156
+	Hs
		400437 RAF1_HUMAN (1-648): 0: 637: 100.00		CDN2B_HUMAN (3-136): 4.73e-52: 163: 81.34
+	Hs
		400742 RAF1_HUMAN (1-648): 0: 637: 100.00		ANK3_HUMAN (3-153): 3.24e-36: 133: 16.94
+	Hs
		400558 RAF1_HUMAN (1-648): 0: 637: 100.00		RIPK4_HUMAN (7-107): 5.52e-26: 104: 22.55
+	Hs
		400438 RAF1_HUMAN (1-648): 0: 637: 100.00		CDN2C_HUMAN (21-135): 9.52e-26: 97.8: 28.21
+	Hs
		400171 RAF1_HUMAN (1-648): 0: 637: 100.00		POTEJ_HUMAN (49-152): 1.68e-19: 85.8: 13.89
+	Hs
		274072 RAF1_HUMAN (1-648): 0: 637: 100.00		ANR17_HUMAN (69-147): 2.29e-19: 85.5: 20.25
+	Hs
		400671 RAF1_HUMAN (1-648): 0: 637: 100.00		ANK2_HUMAN (3-63): 3.65e-14: 70.7: 24.19
+	Hs
		401616 RAF1_HUMAN (1-648): 0: 637: 100.00		RAI14_HUMAN (1-64): 1e-11: 63.4: 21.21
+	Hs
		578414 BRAF_HUMAN (39-647): 9.6e-166: 494: 56.02		CDN2A_HUMAN (1-156): 9.11e-52: 163: 100.00
+	Hs
		578415 BRAF_HUMAN (39-647): 9.6e-166: 494: 56.02		CDN2B_HUMAN (3-136): 4.73e-52: 163: 81.34
+	Hs
		521239 ARAF_HUMAN (44-646): 8.15e-165: 486: 59.18		CDN2B_HUMAN (3-136): 4.73e-52: 163: 81.34
+	Hs
		521264 ARAF_HUMAN (44-646): 8.15e-165: 486: 59.18		RIPK4_HUMAN (7-107): 5.52e-26: 104: 22.55
+	Mm
		98249 BRAF_MOUSE (38-647): 4.12e-164: 490: 55.84		E9Q9B7_MOUSE (86-156): 2.7e-12: 65.4: 19.48
+	Hs
		943985 KSR1_HUMAN (138-648): 4.19e-108: 349: 24.61		RIPK4_HUMAN (7-107): 5.52e-26: 104: 22.55
+	Hs
		1309251 KSR1_HUMAN (138-648): 4.19e-108: 349: 24.61		TANC2_HUMAN (56-154): 1.63e-16: 77.3: 19.00