HitPredict

Interactor 1: K2C1 (P04264)
Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)
Gene: KRT1

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	36470425, 19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 644 Hs			1 906
+	Hs
		651441 KRT84_HUMAN (3-644): 1.04e-93: 303: 44.51		CBL_HUMAN (1-906): 0: 882: 100.00
+	Hs
		566333 K2C5_HUMAN (1-496): 1.95e-79: 264: 64.72		CBL_HUMAN (1-906): 0: 882: 100.00
+	Hs
		407253 K2C6B_HUMAN (2-512): 7e-78: 260: 62.82		CBL_HUMAN (1-906): 0: 882: 100.00
+	Hs
		651220 K2C6C_HUMAN (2-512): 3.57e-77: 258: 62.62		CBL_HUMAN (1-906): 0: 882: 100.00
+	Hs
		651359 K2C79_HUMAN (72-570): 4.11e-77: 257: 56.89		CBL_HUMAN (1-906): 0: 882: 100.00
+	Hs
		385239 K2C6A_HUMAN (2-512): 1.41e-74: 251: 62.43		CBL_HUMAN (1-906): 0: 882: 100.00
+	Hs
		551536 K2C3_HUMAN (152-497): 3.91e-61: 216: 74.14		CBL_HUMAN (1-906): 0: 882: 100.00
+	Hs
		215892 K2C8_HUMAN (152-543): 4.06e-144: 429: 59.44		SYNJ1_HUMAN (391-793): 3.14e-10: 66.5: 11.84
+	Hs
		437302 K2C8_HUMAN (152-543): 4.06e-144: 429: 59.44		ASPP1_HUMAN (460-843): 3.23e-10: 66.1: 12.69
+	Hs
		618158 K2C4_HUMAN (46-505): 3.23e-65: 225: 60.22		ASPP1_HUMAN (460-843): 3.23e-10: 66.1: 12.69
+	Hs
		407371 K2C1_HUMAN (1-511): 1.47e-60: 215: 100.00		NFH_HUMAN (571-860): 9.92e-10: 64.5: 11.72