HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: LRFN1 (Q9P244)
Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2)
Gene: LRFN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	39499777
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Furin-like~fn3, GF_recep_IV~LRR_8, PK_Tyr_Ser-Thr~fn3, LRR_8~PK_Tyr_Ser-Thr, Recep_L_domain~fn3
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 771
+	Hs
		363953 EGFR_HUMAN (16-1253): 0: 1078: 48.80		LRFN1_HUMAN (1-771): 8.7e-153: 466: 100.00
+	Hs
		411039 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		RTN4R_HUMAN (20-325): 1.29e-72: 246: 25.38
+	Hs
		411089 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		FLRT3_HUMAN (1-571): 1.4e-60: 218: 16.44
+	Hs
		411002 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		LRIG1_HUMAN (2-764): 2.16e-36: 149: 12.70
+	Hs
		317541 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		SLIT2_HUMAN (34-296): 1.87e-13: 76.6: 24.72
+	Hs
		410908 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		LRIG3_HUMAN (300-407): 5.23e-09: 62: 25.93
+	Hs
		363825 EGFR_HUMAN (16-1253): 0: 1078: 48.80		RTN4R_HUMAN (20-325): 1.29e-72: 246: 25.38
+	Mm
		999820 EGFR_MOUSE (17-1254): 0: 1135: 48.72		LRIG1_MOUSE (48-764): 4.87e-42: 167: 11.44
+	Mm
		1030080 EGFR_MOUSE (17-1254): 0: 1135: 48.72		LIGO1_MOUSE (1-356): 1.74e-42: 165: 21.61
+	Hs
		363945 EGFR_HUMAN (16-1253): 0: 1078: 48.80		FLRT3_HUMAN (1-571): 1.4e-60: 218: 16.44
+	Hs
		363511 EGFR_HUMAN (16-1253): 0: 1078: 48.80		LRRT4_HUMAN (33-591): 1.98e-56: 205: 15.30
+	Hs
		1145766 ERBB4_HUMAN (6-1232): 0: 1103: 45.86		LRIG1_HUMAN (2-764): 2.16e-36: 149: 12.70
+	Hs
		363706 EGFR_HUMAN (16-1253): 0: 1078: 48.80		LIGO1_HUMAN (1-356): 6.09e-42: 164: 21.61
+	Hs
		363715 EGFR_HUMAN (16-1253): 0: 1078: 48.80		LRIG1_HUMAN (2-764): 2.16e-36: 149: 12.70
+	Hs
		641652 ERBB3_HUMAN (5-1252): 0: 1047: 38.79		LRIG1_HUMAN (2-764): 2.16e-36: 149: 12.70
+	Hs
		1145744 ERBB4_HUMAN (6-1232): 0: 1103: 45.86		LRIG3_HUMAN (300-407): 5.23e-09: 62: 25.93
+	Hs
		320853 EGFR_HUMAN (16-1253): 0: 1078: 48.80		LRIG2_HUMAN (300-405): 1.09e-09: 64.3: 23.59
+	Hs
		363447 EGFR_HUMAN (16-1253): 0: 1078: 48.80		LRIG3_HUMAN (300-407): 5.23e-09: 62: 25.93
+	Gm
		1444604 CLV1B_SOYBN (342-978): 2.27e-134: 437: 15.34		CLV1B_SOYBN (53-459): 5.11e-30: 129: 12.67
+	At
		100209 BAME1_ARATH (383-1010): 1.37e-133: 436: 16.37		F4I3K0_ARATH (2-116): 6.36e-16: 84.4: 11.77