HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: LRFN1 (Q9P244)
Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2)
Gene: LRFN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	39499777
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Furin-like~fn3, GF_recep_IV~LRR_8, PK_Tyr_Ser-Thr~fn3, LRR_8~PK_Tyr_Ser-Thr, Recep_L_domain~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0009986 - cell surface
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 771
+	Hs
		411095 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		LRFN1_HUMAN (1-771): 8.7e-153: 466: 100.00
+	Hs
		363825 EGFR_HUMAN (1-1210): 0: 1246: 100.00		RTN4R_HUMAN (20-325): 1.29e-72: 246: 25.38
+	Hs
		363945 EGFR_HUMAN (1-1210): 0: 1246: 100.00		FLRT3_HUMAN (1-571): 1.4e-60: 218: 16.44
+	Hs
		363511 EGFR_HUMAN (1-1210): 0: 1246: 100.00		LRRT4_HUMAN (33-591): 1.98e-56: 205: 15.30
+	Mm
		999820 EGFR_MOUSE (1-1210): 0: 1267: 90.35		LRIG1_MOUSE (48-764): 4.87e-42: 167: 11.44
+	Mm
		1030080 EGFR_MOUSE (1-1210): 0: 1267: 90.35		LIGO1_MOUSE (1-356): 1.74e-42: 165: 21.61
+	Hs
		363706 EGFR_HUMAN (1-1210): 0: 1246: 100.00		LIGO1_HUMAN (1-356): 6.09e-42: 164: 21.61
+	Hs
		363715 EGFR_HUMAN (1-1210): 0: 1246: 100.00		LRIG1_HUMAN (2-764): 2.16e-36: 149: 12.70
+	Hs
		411039 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		RTN4R_HUMAN (20-325): 1.29e-72: 246: 25.38
+	Hs
		411089 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		FLRT3_HUMAN (1-571): 1.4e-60: 218: 16.44
+	Hs
		320853 EGFR_HUMAN (1-1210): 0: 1246: 100.00		LRIG2_HUMAN (300-405): 1.09e-09: 64.3: 23.59
+	Hs
		363447 EGFR_HUMAN (1-1210): 0: 1246: 100.00		LRIG3_HUMAN (300-407): 5.23e-09: 62: 25.93
+	Hs
		1145766 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		LRIG1_HUMAN (2-764): 2.16e-36: 149: 12.70
+	Hs
		411002 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		LRIG1_HUMAN (2-764): 2.16e-36: 149: 12.70
+	Hs
		641652 ERBB3_HUMAN (1-1205): 0: 1102: 41.39		LRIG1_HUMAN (2-764): 2.16e-36: 149: 12.70
+	Hs
		1145744 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		LRIG3_HUMAN (300-407): 5.23e-09: 62: 25.93
+	Hs
		317541 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		SLIT2_HUMAN (34-296): 1.87e-13: 76.6: 24.72
+	Hs
		410908 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		LRIG3_HUMAN (300-407): 5.23e-09: 62: 25.93
+	At
		1426156 Y3359_ARATH (358-1014): 3.03e-135: 437: 15.62		FLS2_ARATH (2-224): 2.39e-34: 143: 14.04
+	Hs
		320856 RET_HUMAN (412-1058): 7.91e-132: 433: 23.02		LRIG2_HUMAN (300-405): 1.09e-09: 64.3: 23.59